ENGINEERING VACCINE IMMUNITY
…Science Translational Medicine 2018, COI 2018, and Science 2019) Germinal centers (GCs) are the engines of affinity maturation and are the critical source of memory B cells and long-lived plasma…
358 – Chimeric Virus-Host Transcripts Reveal Integration Sites in Macaque SIV+ CD4 T Cells
…integration sites (IS) and their expression. Methods Memory CD4 T-cells from lymph node and peripheral blood collected 2-3 weeks post-SIV infection of two rhesus macaques were single-cell RNA sequenced using SMART-Seq…
HIV DNA Identified in Most Tissues of a Plasma-Negative HIV Autopsy Cohort
…to tissue injury. The National Neurological AIDS Bank (NNAB) and AIDS and Cancer Specimen Resource (ACSR) autopsy cohort was screened to identify 20 HIV+/ART-treated participants who had undetectable plasma and…
HIV Transmission Among Seattle Adolescents
…HIV-infected adolescents would be linked to clusters of infected adults. Methods: Data from time of first HIV genotyping for drug-resistance, including demographics (age, sex, race), HIV transmission risk (men who…
CD32+PD-1+ TFH CELLS ARE THE MAJOR HIV RESERVOIR IN LONG-TERM ART-TREATED INDIVIDUALS
…marker of HIV reservoir in blood memory CD4 T cells. We therefore investigated the distribution of the HIV reservoir in lymph nodes (LNs) memory CD4 T cell populations defined by…
PERSISTENT DYSREGULATION OF HIV-SPECIFIC T FOLLICULAR HELPER CELLS DURING ART
…(Ag)-specific Tfh, previous studies on mechanisms of Tfh impairment have been restricted to bulk Tfh. Therefore, it remains unclear if this Tfh dysfunction is HIV-specific or reflects a global dysregulation…
Pharmacokinetic and Pharmacodynamic Evaluation of NNRTI IQP-0528 DuoGel™ in Macaques
Background: Unprotected receptive anal intercourse (RAI) is also practiced by women, providing strong rationale for the development of an HIV microbicide gel that is suitable for both rectal and vaginal…
CHARACTERIZATION OF FDC-BOUND VIRAL PRODUCTS DURING HIV/SIV INFECTION
…FDC-bound viral products during HIV/SIV infection. Formalin fixed paraffin embedded (FFPE) lymph nodes (LNs) from acutely infected (7 dpi) and chronically infected (Non SAIDS, 69-118dpi) rhesus macaques or chronically HIV-infected…
ARMY LIPOSOMAL SPIKE FERRITIN NANOPARTICLE VACCINE INDUCES DURABLE IMMUNE RESPONSES
…SpFN formulated with either Alhydrogel (SpFN+AH) or ALFQ (SpFN+ALFQ) and immunological assessment from the vaccine draining lymph nodes (dLNs), lung and spleen was performed to assess cellular engagement and cytokine…
INNATE IMPAIRMENT DURING SIV INFECTION ALTERS ZIKV VIRAL PATHOGENESIS
…were measured by qRT-PCR. Blood/peripheral blood mononuclear cells (PBMCs), lymph node, and rectal tissues collected pre- and post-SIV and/or ZIKV infection were evaluated for innate and adaptive immune responses by…