…decreased in the presence of SF162 V3 as compared to the scrambled peptide and no peptide (median ID50 671, 1399, 2930, for SF162 V3 peptide, scrambled peptide, and no peptide,…
…responses. Furthermore, competitive peptide assays revealed that polymorphisms selected by HLA-B39:02 alter peptide binding affinity to the HLA molecule. Methods We recruited a cohort of 14 men living with HIV…
…CTL epitopes within structurally important HIV protein regions that avoid CTL immune escape mutations. Methods: Employing the IMAP, we generated 8-14 mer overlapping peptides containing amino acid residues that are…
…convenient outreach points for HIV prevention services including PEP. We assessed the willingness of AGYW seeking ECP to test for HIV and initiate PEP Methods: We assessed willingness to test…
…of doxycycline PEP in that trial was low. Methods We describe 35 breakthrough cases of incident Chlamydia trachomatis among 32 participants assigned to doxycycline PEP (n=224) within an open-label randomized…
…doxy-PEP among SGM in Brazil. Methods A cross-sectional online survey was conducted among adults (18+ years) living in Brazil, recruited via advertisements on dating apps (Scruff and Grindr) and social…
Background Doxy-PEP is an effective strategy for STI prevention, with absent data from Latin America. ImPrEP (2018–2021) evaluated same-day oral PrEP delivery for MSM and TGW in Brazil, Mexico, and…
…a convenience sample of DoxyPEP trial participants (ppts). Men who have sex with men (MSM) and transgender women (TGW) with HIV or on PrEP were randomized 2:1 to doxy-PEP or…
Background Doxycycline post-exposure prophylaxis (doxy-PEP) effectively prevents bacterial STIs among men who have sex with men (MSM) and transgender women (TGW). The real-world impact of doxy-PEP will depend partly on…
…had previously used PEP. Most (86%) were men who have sex with men. Medication adherence was high; among 101 participants with available data, all took all 28 days of PEP…