…the effect of first-line ART with DTG+3TC versus one standard 3-drug regimen (3DR) on the dynamics of viral persistence in lymph nodes and peripheral blood and on immune activation biomarkers…
…tissue (spleen, lymph node, gut) from virally suppressed PWH (n=6; undetectable plasma viral load for a median of 3.41 years) were provided by the National NeuroAIDS Tissue Consortium. HIV LTRs…
…software in Python. AFQ produced fractional anisotropy (FA) and mean diffusivity (MD) values at each of 100 equidistant nodes along each of 22 major WM bundles. We analyzed group differences…
…≥1 CVD risk factor. CHIP mutations were detected from peripheral blood mononuceleic cells with a validated targeted sequencing assay. We measured carotid intima-media thickness (IMT) longitudinally with ultrasound and aortic…
The aim of this study was to assess immune activation in various organs by longitudinally measuring changes in glucose metabolism associated with initiation and interruption of combination antiretroviral therapy (cART)…
Single cell.methods have enhanced the resolution at which cells in blood and tissues can be studied in people with HIV (PWH). Yet, capturing the native multi-omics state of cells obtained…
…?g/g liver, 9.0 ± 2.1 ?g/g spleen, 8.3 ± 1.7 µg/g kidney, 14.0 ± 3.2 µg/g lymph nodes (mean ± S.E.M.). A high tissue to plasma ratio of drug was…
…non-WA) of each node. Internal node date for the MRCA of each subclade of two or more sequences or the date of sampling for singletons was assumed to be the…
…CNS with the greatest number in the cervical lymph node 7 days after SPION administration. This timing was consistent in both SIV-infected and control animals. We determined that SPIONs are…
Follicular T helper CD4+ (Tfh) cells play a critical role in germinal center (GC) formation and B cell maturation. GCs in lymph nodes (LN), particularly within Tfh cells, are sites…