…that package the lentiviral accessory protein Vpx. Vpx increases DC transduction by two-logs allowing for long-term antigen expression, a significant improvement over peptide-pulsing. To test this approach, we generated vectors…
…feasible among women taking PrEP and PrEP providers in Kenya Methods: We conducted semi-structured in-depth interviews with 17 women on PrEP who were enrolled in the POC assay arm of…
…antigens would differ by HIV status. Methods: CD4 and CD8 T cell responses to peptide pools spanning 19 CMV open reading frames (ORFs) were measured by intracellular cytokine staining for…
…model compound. Understanding the mechanism of action of MIs in greater detail may be of value to help guide the development of MIs with improved genotypic coverage. Methods: In this…
…women with BV (Nugent >7), and without BV (Nugent <5). We used flow cytometry to assess phenotype and functionality of neutrophils, and performed in vitro whole blood co-cultures with bacteria…
…viral load (VL) among PLWH switching to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD). Methods: The longitudinal African Cohort Study (AFRICOS) enrolls PLWH engaged in routine care at 12 PEPFAR-supported facilities in Kenya,…
…From February-May 2025 through the Transgender Women’s Internet Survey and Testing (TWIST) study, we recruited transgender women and transfeminine nonbinary persons assigned male at birth (hereafter “tranfems”) in the United…
A betulinic acid-based compound, bevirimat (BVM), the first-in-class HIV-1 maturation inhibitor, acts by blocking a late step in protease-mediated Gag processing: the cleavage of the capsid-spacer peptide 1 (CA-SP1) intermediate…
Like other type 1 fusion machines, the HIV-1 envelope (Env) trimer transitions between prefusion, pre-hairpin intermediate and postfusion conformations to merge viral and host cell membranes during virus entry. In…
…phase 2b clinical trial, we observed significant effects of the glucagon-like peptide-1 receptor agonist (GLP-1 RA), semaglutide, over 32 weeks on key outcome measures, including reductions in weight, total body fat,…