…and lymph nodes since the earliest stage of acute infection (Fiebig I) and their frequency increased with time. Phenotypic analysis of 12,067 p24+ cells from blood and lymph nodes showed…
…virus was median=9.9%. Only a small proportion of the intact provirus population was inducible (median=5.7%, IQR=3.3-10.8%) with an even smaller subset of inducible defective provirus (median=1.3%, IQR=0.9-2.3%). Intact and inducible…
…presented as geometric mean (median range) and geometric mean ratio (GMR). Analyses were performed using Pearson Correlation, Kruskall-Wallis, and Mann-Whitney Rank Sum tests (p<0.05). ARV concentrations are summarized in the…
…proportion of people with a current PrEP/PEP indication who take PrEP/PEP and hence reduce HIV incidence relative to status quo over 10 years; median (90% range) across setting-scenarios HIV incidence…
…by ELISA using 7 overlapping peptides spanning the whole ASP. 96-well flat-bottom plates were coated overnight with the synthetic peptides (1 peptide/well). Sera were diluted 1:200 prior to screening. Goat…
…protease inhibitor (SLPI), and lysozyme – at the time of PVI (compared to a neutral control for time levels) and assesses effects on in-vitro HIV inhibition. Methodology: 40 healthy women…
In 2016, the Presidents Emergency Plan for AIDS Relief (PEPFAR) initiated the DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe women) programs in10 sub-Saharan Africa countries including Uganda to reduce risk of HIV and domestic…
…Self-Assembly platform measuring IgG binding to 286,793 peptides from >500 viruses. Analyses included antibodies reactive in ≥10% of cohort. Associations with CI (global and seven cognitive domains) were evaluated using…
…from HIV infection. Previously we described a 34 amino acid peptide from the C-terminal heptad repeat-2 domain of gp41 (C34) which, when fused to the amino terminus (NT) of either…
Background: Doxycycline postexposure prophylaxis taken following a condomless sexual exposure reduces incident bacterial STIs among men who have sex with men but not among cisgender women in initial trials. Adherence…