CD8 T-cells play a pivotal role in clearance of HIV-infected cells, such that CD8 exhaustion contributes to their dysfunction and consequently, viral persistence. Mesenteric lymph nodes (MLNs), which drain the…
…after analytic treatment interruption (ATI; range 65-225,000 c/mL). Methods To identify CD8+ T cell features that correlate with subsequent post-ATI pVL set point, we performed spectral flow cytometry including SIV-specific…
…(N=6) in combination with either efavirenz (EFV) + raltegravir (RAL) (N=3), cohort FTER, or maraviroc (MVC) + atazanavir (ATZ) (N=3), cohort FTMA. Tissue accumulation of ARVs and metabolites was measured…
…the immune activation associated with HIV infection. Methods We evaluated the influence of HIV infection on the functional and transcriptomic profile of lymph node (LN) myeloid dendritic cells (DCs) subsets during both chronic…
Background In HIV/SIV infection, CD8 T and natural killer (NK) cells are critical antiviral effectors, yet the exact mechanisms for their inability to mediate durable viral control remains unclear and…
Chronic HIV infection is characterized by persistent inflammation and immune activation that can lead to tissue injury and fibrosis. Lymph node (LN) fibrosis may limit CD4+ T-cell recovery; LN and…
…nodes expresses CXCR5, indicating ability to migrate into germinal centers where chronically infected CD4+Tfh reside. MCI confirmed the presence of effector CD8 cells in germinal centers and showed that these…
…memory (CM), transitional memory (TM) and effector memory (EM). T cell subsets were sorted from 32 people with HIV on ART, including 11 with matched PBMCs and LN, 5 virologically…
…observed increase in IgG plasma levels. In lymph nodes the increase in follicular and germinal center B cells point towards a restoration of lymph node architecture. Overall, these data suggest…
…impact that PEPFAR had on the disease when it arrived in the country in 2004. They discuss how PEPFAR has operated in Zambia and provide a current overview of the…