…disease progression or clearance at anal site. Methodology: We enrolled HIV+ men who underwent anorectal swabs for HPV-PCR detection/genotyping (High Risk HR) and cytologic abnormalities (Bethesda 2001: Low and High…
…of CD62L (L-selectin), an adhesion molecule that controls T cell migration into lymph nodes. TCR stimulation suppresses Foxo1 activity through PI3K/Akt-dependent phosphorylation of Foxo1 and its relocation to the cytoplasm….
…HIV evolution occurs on ART at a rate of 6×10^-4 to 1×10^-3 mutations/site/month due to ongoing viral replication in the lymph nodes with subsequent trafficking of newly infected T-cells to…
…autologous hematopoietic stem cell transplantation (aHSCT) in SIV-infected, ART-treated rhesus macaques (RM) to interrogate the origin of the SIV reservoir. Methodology: This pilot study included three SIV-infected RM who received…
…replication, at or near peak viral replication, or in early chronic infection. Methodology: To test the effect of timing of treatment on viral reservoirs, RM infected intravenously with SIVmac239 were…
…5 lymph nodes, spleen). In animals necropsied after 9 months on ART, total and intact proviral DNA in was ~10X higher in CD4+ T cells (median 3.5 x 103 total…
…goal can only be achieved by identifying the cellular localization of the HIV reservoir, the molecular mechanisms that result in the establishment and maintenance of latent infection and host determinants…
…T cell subsets. In 9 LoViReTs with <0.1 infectious units per million (IUPM), total HIV-DNA was measured in rectal and/or lymph node biopsies (LN). Clinically matched individuals with HIV-DNA >50…
…administered with MSC by adoptive transfer and compared with SIV-infected and SIV-negative animals without MSC treatment. Virologic, immunologic, transcriptomic, metabolomic and microbiota (16s sequencing) analyses were performed. SIV RNA loads in…
High HHV-8 viral load (VL) has been associated with severe Kaposi sarcoma (S-KS). KS Immune reconstitution inflammatory syndrome (IRIS) can occur in patients after starting cART with associated high mortality….