30% of HIV-infected subjects fail to increase their CD4 T-cell lymphocyte counts during combination antiretroviral therapy (cART) and remain both inflamed and immunodeficient. These individuals are termed “immunological non-responders.” Systemic…
As HIV-1 infection has transformed from a fatal crisis into a chronic, life-long disease managed by anti-retroviral therapy (ART), attention has shifted towards curative therapies. A regimen which may allow…
…analyses were performed by Wilcoxon matched-pairs signed rank test using GraphPad Prism 6. %GFP+ is higher in TFR compared to TFH (median, 4.8-fold higher; p=0.008) and in GC TFR compared…
…Total HIV-DNA and intracellular HIV-RNA were quantified by qPCR in purified CD4+ T cells. P24 expression and MDSC infiltration in B-cell follicles within lymph nodes of n=2 chronic infected patients…
…control animals (n=7) only infected with ZIKV (SIV-/ZIKV+). SIV and ZIKV viral loads in plasma and peripheral tissues were measured by qRT-PCR. Blood/peripheral blood mononuclear cells (PBMCs), lymph node, and…
Antiretroviral therapy (ART) requires lifelong daily dosing to attain durable viral suppression. However, regimen adherence dictates effective long-term clinical response by precluding viral rebound. To improve ART effectiveness and ensure…
…to eliminate abnormal and/or infected cells, through distinct mechanisms, including ADCC. Studies of macaques and AGM chronically infected by SIV have revealed the presence of adaptive and memory NK cells….
…the effects of N-803 on T cells and NK cells in peripheral blood (PBMC) and lymph nodes (LN). Methods Participants with AHI (Fiebig I-IV) were randomized in an open-label manner…
…were measured by ddPCR and cellular immune dynamics by flow cytometry. Results IL-15SA treatment transiently increased frequencies of total memory CD8+ and SIV Gag CM9-specific CD8+ T cells in blood…
…As such, developing interventions aimed at improving immune responses is a key priority for HIV cure strategies. Here, we investigated the effects of a combined heterodimeric IL-15 (hetIL-15) and IL-21 treatment….