…T cell reconstitution was associated with a massive burst in memory T cell proliferation as measured by Ki67, which peaked around 3-4 weeks post-ATM and followed by a gradual recovery…
HIV+ persons with low CD4…
…method was performed on each of the wells, generating multiple copies of genomic DNA in each well. Aliquots of the MDA products were then used to obtain the integration sites…
…RMs that had rebound viremia after ART stop, as controls. We assessed multiple endpoints including: viral outgrowth (VOA) and viral co-culture (VCC) using lymph node mononuclear cells (LNMC) and PBMC….
…of variants in plasma samples. NGS uSGS libraries were generated by tagging cDNA molecules from plasma RNA with primer IDs, optimizing PCR, and generating overhangs on amplicons for efficient ligation…
…tissues. Importantly, a significant increase in cytotoxic effector memory CD8+ T cells was found in lymph nodes (LN) from all hetIL-15-treated macaques. CM9 tetramer staining demonstrated that the increase of…
…mount this type of humoral response and the lymph node (LN)–specific parameters associated with such outcomes in the context of persistent viremia remain to be elucidated. To address this question,…
…the transmitted functional viruses into defective viruses mainly via frameshift mutation. Future study to elucidate the role of FVS and mechanism of frameshift mediated conversion of functional viruses into defective…
…sequences (mean 109 [95%I:72.7 -145.6]/participant) across 32 distinct blood and tissue sites (mean 20 [95%CI:14.4-26.6] sequences/site) from 6 participants. We observed expected heterogeneity of predicted neutralization susceptibilities across participants but…
…every two weeks while maintaining ART. We longitudinally assessed plasma SIV RNA, total SIV DNA in PBMCs, lymph node (LN) and colon biopsies, and ex vivo SIV production from LN…