The large majority of the studies on B cells in HIV-1 infection have been performed in blood. Limited information is available on B cell populations from lymph nodes and on…
The large majority of the studies on B cells in HIV-1 infection have been performed in blood. Limited information is available on B cell populations from lymph nodes and on…
Background How HIV reservoir is established in lymphoid tissues remain elusive. Methods We obtained frozen lymph nodes from 2 viremic donors and 2 virally suppressed donors from the Last…
Lymph nodes have been implicated as potential sanctuary sites of ongoing HIV replication during ART due to inadequate drug penetration. To investigate this possibility, we characterized HIV proviral populations, their…
…helper cells (TFH) located within B cell follicles (F) of secondary lymphoid tissues including lymph nodes, spleen, and GALT. In lymph nodes from untreated people, HIV-specific CTL fail to accumulate…
…lymph node uptake of gadolinium G5-DOTA dendrimer (~8 nm diameter simulated particulate antigen) after intradermal injection into the anterior portion of the feet. MRI was performed prior to SIV infection…
…signatures during early versus late viral rebound. Understanding these immune signatures and their respective immune cell subsets throughout viral rebound provides mechanisms for immune control. Methods: From 2 female rhesus…
…the majority of HIV replication in EC likely occurs in lymphoid tissue, where CD8+ T cell immune surveillance mechanisms are undefined. Here we performed single-cell RNA sequencing (scRNAseq) analyses to…
…evaluated the cell types producing SIV in dCLN, axillary lymph nodes (AxLN), and mesenteric lymph nodes (MesLN) in three SIVmac251-infected rhesus macaques 14 days post-ATI. Animals were CD8-depleted before and…
…detected in c. 3-10 lymph nodes in both participants (SUVmax 1.14 – 6.4), indicating increased metabolic activity was present in these tissues. Metabolically active nodes were present in mediastinal, axillary…