…a1DC), and pulsed with 1 of 2 antigen sources (HIVconsvX conserved pol/gag peptides or autologous inactivated HIV-1) or no antigen (control). Methods Eligible participants (ppts) were adults with HIV RNA…
…fiscal years, FY21 – FY24. Methods We analyzed PEPFAR Monitoring, Evaluation, and Reporting data for all CLHIV <15 yo on ART with IIT between October 2020 and June 2024 (FY21-FY24)…
…8 pts (7%) discontinuing PEP because of gastro-intestinal adverse events (AEs). Gastrointestinal AEs were reported in 61 pts (53%) and 47 pts (41%) in the PEP and no PEP arms,…
…curb new HIV infections globally. In 2024, PEPFAR-supported injectable cabotegravir (CAB-LA) was introduced to expand HIV prevention options in five initial countries. Methods CAB-LA was introduced in 105 facilities in…
…to enable PEP use within 24 hours of sex. Giving unrestricted access would mean drugs might also be used as PrEP, and as ART for people with HIV, without engagement…
…private pharmacies, may help enhance PrEP reach and coverage. We assessed PrEP product preferences among clients obtaining daily oral PrEP or post-exposure prophylaxis (PEP) at private pharmacies in Kenya. Methods…
…virus via antigen-specific memory NK responses. Methods: To study antigen-specific NK cells in NHP, we developed a novel in vitro method to clonally expand single rhesus macaque (RM) NK cells…
…MoBi, where a lymph node compartment was added. Physiologic parameters describing the lymph node were obtained from literature. The lymph node model was exported back to PK-Sim, and fit to…
…Medical Image Merge Software (MIM®). Cervical, mediastinal, axillary, and inguinal lymph nodes were identified manually and verified by a board-certified Nuclear Medicine radiologist. Metabolic activity in lymph nodes was quantified…
…T cell responses to S815-827. All responders also recognized homologous peptides from at least 2 other coronaviruses, and 8 out of 11 responders recognized peptides from at least 6 out…