…ago, when testing methodologies were less specific than with current technology. The RV254/SEARCH010 cohort has recruited participants with AHI in Thailand since 2009. A total 230,036 screening tests were done…
…active TB disease. Accordingly, the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) is committed to providing TPT to the eligible 14 million PLHIV currently supported by this program. In…
…Selected identified phosphorylated HIV-1 peptides were synthesized and tested for HLA class I binding. PBMCs from HIV-1 infected patients were stimulated with phosphorylated and non-phosphorylated peptides, followed by flow-cytometric analysis…
Background: We evaluated the safety, tolerability, and immunogenicity of a therapeutic HIV vaccine composed of autologous dendritic cells (DC) pulsed with autologous, inactivated, HIV-1 infected apoptotic cells (DC-HIV vaccine). Methodology:…
…and performed TCR sequencing on epitope-specific T cells. Epitope mapping was performed by IFN? ELISpot on PBMC from SARS-CoV-2 convalescent patients with mild/moderate disease (n = 19 for S; n=15…
…HIV peptide pool stimulation (p=0.05), and trends for lower % polyfunctional CD4+ T cell responses to pol (p=0.07), env (p=0.06) and total HIV peptide pool (p=0.052). Although no single immune…
…subjected to a 5-drug antiretroviral regimen + nicotinamide, a drug aimed at disrupting HIV latency and boosting cell-mediated immunity (NCT02961829). He had been in antiretroviral analytical treatment interruption (ATI) for…
…via different routes, ALVAC prime/ AIDSVAX boosts, ALVAC prime/ Env protein boosts, DNA prime/ Ad5 boost, subtype B gp120 alone, and MVA alone. Chronically infected HIV specimens were used as…
…with subtype CRF01_AE, remain sparse. Although HLA-B*57 is a protective allele amongst Africans and Caucasians, its prevalence amongst Asians is lower than other ethnic groups. Methodology: 1) 557 HIV-1 CRF01_AE-infected…
In March 2020, the Brazilian Ministry of Health (MoH) announced COVID-19 countrywide community transmission and issued guidelines on social distancing measures. Using real life data, we aimed to analyze the…