…control of viremia to < 10,000 copies/mL. Lymphocyte populations in blood, bronchoalveolar lavage fluid, lymph nodes, colon, and jejunum were enumerated via flow cytometry. Plasma viremia was measured via quantitative…
…vDNA+ cells. In addition, SIV-infected RMs treated with aIL-10 vs control group were compared for their vRNA and vDNA levels in lymph nodes (LNs); scRNA-seq and scATAC-seq was also performed…
…and outcomes of patients with disseminated KS, with and without pulmonary involvement. Methods We conducted a single-center retrospective cohort study from 2018 to 2024, including people with HIV and biopsy-confirmed…
Recently, a novel innate immune cell subset termed natural killer-like B (NKB) cells was identified in mice that rapidly responded to microbial infection and primed the innate antiviral response. Despite…
…impaired CD4+ T-cell migration to the intestine and lymph nodes. SKAP1 has never been described in the context of HIV. Methods: The 2000HIV study (clinicaltrials NTC03994835) is a Dutch cross-omics…
…KSHV DNA in multiple anatomic sites, such as oral cavity, respiratory tract, kidney and lymph nodes. The KSHV seronegativity of these 7 donors was further confirmed with ultra-sensitive serological assay VirScan. Conclusions…
…pol masked the emergence of new viral variants and/or compartmentalization, we applied the same methods to the more diverse env gene in the infected macaques. Methodology: Two macaques (M03250 and…
…metagenomic sequencing was performed to analyze taxonomic composition and functional profiles of the gut microbiota bioinformatically. We also investigated associations between microbial diversity and immune markers, including NKG2A, viral (v)RNA…
…in infants and another subset was followed longitudinally. Viral loads in plasma and tissues were measured by qPCR. Binding and neutralization antibody responses were quantified by ELISA and focus reduction…
…backbone of SHIV-KU2, lacking the integrase gene. In our earlier studies we demonstrated persistent Gag- and Nef-specific CD4+ and CD8+ T precursors (PHPC), central memory (Tcm) and effector memory (Tem)…