…(Doxy PEP: 200 mg within 72h of condomless sex) or no PEP (2:1); and 2 shots of meningococcal B vaccine (Bexsero°) or no vaccine (1:1). Participants were tested centrally at…
…We examined whether a single injection of the combination of long-acting cabotegravir and rilpivirine (CAB LA and RPV LA) could be an effective PEP regimen in macaques. Methods: Human equivalent…
Background: Doxycycline post-exposure prophylaxis (doxy-PEP) reduces bacterial sexually transmitted infections in men who have sex with men (MSM) and transwomen (TW) living with HIV or on HIV pre-exposure prophylaxis (PrEP)….
…complex with cyclic peptide (cyFG5) by X-ray crystallography. This structure was compared to reported WT unliganded, PF74-bound, and Nup153 peptide-bound structures (PDB: 4XFX, 4XFZ, 6AYA). Site-directed mutagenesis was performed on…
…CoV-2 proteome. We synthetized a 15-mer peptide library of 2790 peptides (11 amino acid overlap) covering a CoV-2cons proteome sequence based on 1700 sequences. We designed a mega matrix of…
Background: Persons with HIV have an increased risk of developing diabetes mellitus. The ratio of immature (Pro-insulin) relative to mature (C-peptide) insulin products (PI:C) in circulation serves as a biomarker…
Background: Clinical trials of Doxy-PEP demonstrated high efficacy in preventing bacterial sexually transmitted infections (STIs) among men who have sex with men but not in women. Low Doxy-PEP efficacy observed…
…enhanced an electronic medical record system by developing a HTN module to monitor this subpopulation for outcomes of interest. Antiretroviral (ART) adherence was measured using pill counts. From 2/15 to…
…estimating equations. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were reported with all characteristics adjusted for each other except PEP; PEP was adjusted for all others. At initial…
…underrepresented in clinic-based PrEP/PEP programs (e.g., men, unmarried individuals) and is highly acceptable and feasible to pharmacy clients and providers. Implementation challenges, however, include heavy burden on provider time (particularly…