…the structural basis for the co-evolution of I50V/A71V protease with the p1-p6 substrate. Methods: By applying crystallography method and molecular dynamics simulation, we investigate the structural basis of I50V/A71V protease…
…binding to spike-expressing 293T cells. For CD4+ T cell response analyses, cytokine production was measured by intracellular staining on primary T cell lines stimulated by immunodominant peptides derived from the…
Topical products for HIV prevention that can be administered on-demand, either pre- or post-viral exposure, remain an advantageous regimen for end-users that have infrequent or clustered intercourse or are unable…
Tapasin (hereafter TAPBP) is a transmembrane glycoprotein mediating the binding of TAP and MHC-I within the peptide loading complex in the endoplasmic reticulum, the interaction of which is important for…
…Monitoring, Evaluation, and Reporting (MER) data to assess potential loss to follow-up (LTFU) across PEPFAR countries in SSA before and during the pandemic to determine the impact of COVID-19 on…
…Nanopore. DNA methylation was analyzed for both 5-methylcytosine (5mC) and N6-methyladenosine (6mA). An algorithm was developed to identify genes and genomic sites potentially associated with HIV inducibility. Transcriptome and epigenome…
…a membrane context and potentiate its neutralization of HIV-1. Methodology: Antibody residue positions in the vicinity or co-planar with the gp41 contact interface, though not within it, were chosen for…
…and determine JCV-specific cellular response during prolonged exposure to the drug. Methodology: We enrolled 39 JCV-seropositive MS patients, including 32 on natalizumab monotherapy for 18-20 months (n=14), 22-25 months (n=7)…
Background: Cognitive impairment (CI) in people with HIV (PWH) is associated with abnormal erythrocyte indices, which may result from inflammation, disturbed iron metabolism, and other factors. Mean corpuscular volume (MCV)…
…to redirect CMV-specific CTLs to eliminate HIV-1 Env-expressing cells and suppress HIV-1 infection. Methods: Donor PBMC treated with NLV-VRC01 RediTac to expand NLV-specific memory CTLs were cocultured with either an…