…Plan for AIDS Relief (PEPFAR) countries. Performance of PSC dried plasma spots were compared to centrifuged plasma samples using HIV negative whole blood spiked with cultured virus or using the…
…it is crucial to identify TCR clonotypes which confer the most potent anti-HIV activity. CTLs with superior antiviral efficacy, termed effective CTLs, are well-represented in HIV-1 controllers but are rare…
…week 20. P24 SIMOA (iP24) was measured in CD4+ T cells cultured for 16-hour with medium or PMA/Ionomycin using single molecule array (SIMOA). Intact, 5’ defective, 3’ defective and total…
…Prepared DBS were stored at -80°C until day of testing. Testing was performed on a cobas 6800 system (c6800) using the HIV-1/HIV-2 DBS Qual workflow and reagent kit. The limit…
Background: Although pre-exposure prophylaxis (PrEP) has been recommended by the CDC to prevent HIV transmission among men who have sex with men (MSM) and heterosexuals who engage in condomless sex…
Background: Semen enhances HIV infection in vitro, and semen-derived amyloids made up of a peptide from the abundant protein semenogelin 1 (SEM1) are sufficient to mediate this activity. We sought…
…future research. (Themed Discussion-05) Targeting the HIV Reservoir: Novel Cure Strategies (Themed Discussion-06) Extra Large Challenges in Steatotic Liver Disease (Themed Discussion-07) Precision Comes to Public Health (Themed Discussion-08) Machines,…
…of CD4+ cell counts, viral loads (VL), and treatment gaps on LTFU in a time-dependent fashion. Methodology: From 2004-2012, Harvard/APIN received PEPFAR funds (HRSA #U51HA02522) to support and develop a…
…President’s Emergency Plan for AIDS Relief (PEPFAR). We analyzed TB screening and diagnostic testing data collected at PEPFAR-supported sites during October 2017–March 2019. Countries reporting TB screening data with ≥90%…
Background In January 2025, U.S. foreign aid, including the President’s Emergency Plan for AIDS Relief (PEPFAR), was disrupted. While modeling studies have projected population-health consequences, no population-representative studies have quantified…