…late step in protease-mediated Gag processing: the cleavage of the capsid-spacer peptide 1 (CA-SP1) intermediate into mature CA. BVM was shown to be safe and effective in reducing viral loads…
…a steatohepatitis surrogate) occurred in women (women: 68% to 42%, p=0.06; men: 43% to 41%). Significant changes in adiponectin (↑), leptin (↓) and CRP (↓) were observed, with no change…
…centers. Plasma viral load measurements obtained during the chronic phase of untreated infection were available for 6,315 individuals of European ancestry. Missing genotypes were imputed using the 1,000 Genomes Project…
…Distinct metabolic features, such as increased mitochondrial mass (MM), decreased mitochondrial membrane potential (MMP), and increased reactive oxygen species (ROS) content are related to greater antigen-specific exhaustion. Yet, the contribution…
…was assessed in 15 PLWH after stimulation with HIV-1 peptide pools and measurement of IFNγ production, degranulation (CD107a), and cell proliferation (CFSE). Results: CD4+ and CD8+ TRM cells were significantly…
…with 677 injections (median 3; range 1-12). Users were 52% White, 32% Black, 18% Latino, median age was 34 years (range 21- 62), 2% women, 80% men who have sex…
…Combining HESN and low-risk control women, compared to women not using hormonal contraception, DMPA users had significantly higher mean levels of HNP1-3 (2.38 vs. 2.05 log10 ng/ml; p=0.024) and LL-37…
…cytometry, and T cell intracellular cytokine staining was performed on PBMCs stimulated with an HIV [i]gag[/i] peptide pool. We obtained a total of 1193 proviral genomes. PTCs had approximately 6-fold…
Loss to follow-up (LTFU) in Zambia’s national treatment program threatens progress toward achieving HIV epidemic control. With CDC/PEPFAR funding, the Centre for Infectious Disease Research in Zambia (CIDRZ) supports the…
…transmission to achieve epidemic control. The PEPFAR team in Nigeria introduced recency testing in 2020. We analyzed recent infection among newly diagnosed PLHIV in 10 states. Testing for recent infection…