Background Following evidence of doxycycline postexposure prophylaxis (doxyPEP) efficacy to prevent chlamydia, gonorrhea and syphilis among men and transgender women who have sex with men, Public Health – Seattle &…
…peptide arrays enable the determination of antibody reactivity to as many as six million peptides in a single assay. Identification of antibodies capable of binding a wide variety of HIV…
…immunogenicity of these IMAP-peptides, we assessed the CD8 T cell responses to the total HIV-1 IMAP peptide pool (182 peptides) and IMAP-peptides pooled by HIV-1 protein. Methods We collected peripheral blood…
Background: CDC recommends 3-drug post-exposure prophylaxis (PEP) with emtricitabine-tenofovir disoproxil fumarate (FTC-TDF) plus raltegravir (RAL) for 28 days. But in one non-occupational (N)PEP study, FTC-TDF-RAL adherence was imperfect (only 52%…
Background: CDC recommends 3-drug post-exposure prophylaxis (PEP) with emtricitabine-tenofovir disoproxil fumarate (FTC-TDF) plus raltegravir (RAL) for 28 days. But in one non-occupational (N)PEP study, FTC-TDF-RAL adherence was imperfect (only 52%…
…transmission signature has been identified in the signal peptide of Env. This signature involves the over-representation of basic residues at a specific position in the signal peptide. We investigated the…
…exposures). PEP regimens varied among time (Figure). Overall, 20% of individuals discontinued their PEP regimen within 20 days. Age (OR, 0.87 per 10-years increment [0.83-0.92]), MSM (OR, 0.59 [0.47-0.73]), intercourse…
…is obtained per New York State PrEP/PEP Guidelines. Using electronic medical record data from the PrEP/PEP initiation visit, we examined HCV testing, demographics, incident sexually transmitted infections, and reported sexual…
…breadth on a cross-clade panel of 208 strains with geometric mean ID50 titers of ~100, a level of potency recently shown to protect against mucosal SHIV challenge from fusion peptide-directed…
…from the virus lumen. The prototype peptide triazole thiol KR-13 (R-I-N-N-I-X-W-S-E-A-M-M-βAQ-βA-C-CONH2, X= ferrocenyltriazole-Pro) causes p24 release, however KR-13b (C-terminal SH capped by acetomidomethyl) inhibited cell infection but did not cause…