…follicular helper cells (median 20% vs. 14%), and preferentially expressed CXCR3 (median 46% vs. 35%). There was a direct correlation between the magnitudes of HIV-specific TH measured by the AIM…
…TDF/FTC/RAL 1 wk after diagnosis. Individuals received ChAdV63.HIVconsv (5×1010vp, im) and MVA.HIVconsv (2×108pfu, im) 8 or 24 wk after (Short vs Long regimen) and were followed for 6 months. Immunogenicity…
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…instability, and 22% with substance use. Median number of injections was 9 (IQR 5,14). Mean (SD) satisfaction using LA-CAB/RPV was 61.5/66 (5.3), and 74% reported mental well-being as better with…
…the relationship is damped in mesenteric lymph node, suggesting a uniquely immunosuppressive environment that could enhance viral persistence. IFN signatures decayed rapidly after ART initiation, although remained elevated in lymphoid…
…on antiretroviral therapy (ART), there has been little evaluation of the kinetics of immune reconstitution. We prospectively evaluated HIV and CMV viral loads, and immune reconstitution measured by CD4 and…
…otherwise must be on ART for their lifetime. The objective of this study was to evaluate the immunological and virological impact of DNA/MVA/Protein-based therapeutic vaccination in a pediatric model of…
…innate immune signaling outcomes within cells infected with HCV or HIV defines viral regulation of IRF3, and suppression of ISG products, as shared feature of chronic virus infection. Our studies…
…initiation, plasma viral loads in all animals were stably suppressed to <15 viral RNA copies/ml. Consistent with limited reservoir establishment, cell-associated vDNA measurements were low in PBMC (median 1.7 vDNA…
Background: Upon infection, HIV quickly disseminates and establishes persistent infection throughout the body. The persistence mechanisms of HIV in tissues are complex, with viral and local environment interaction contributing to…