…potential transmission partners). Propensity for clustering within the NYC network was not uniform: men who have sex with men (MSM) were more likely to cluster than heterosexuals (OR =2.4; p…
…U.S. HIV transmission network. Methodology: We analyzed 41,294 HIV-1 pol sequences collected through the U.S. National HIV Surveillance System (NHSS) during 2001-2012. We aligned sequences (one/person aged ≥13 years) to…
…resting memory B cells decreased in the blood but increased in the LNs and gut of PTMs. Circulating tissue-like memory B cells increased in blood only in PTMs, while in…
Background: The CD39/CD73/adenosine (ADO) pathway was associated with immunosuppression in multiple diseases; yet, its precise role in mediating immune activation and inflammation (IA/INFL) during HIV-1/SIV infection remains unclear. Methodology: We…
…which allows precise control over the level of pre-ART evolution and subsequent changes to the viral population. Methods: We infected 21 rhesus macaques with the barcoded virus SIVmac239M to compare…
…translocated bacterial species. Viable bacteria that had translocated were isolated from mesenteric lymph nodes, livers, and spleens obtained from end-stage, SIV-infected RM, cultured under aerobic and anaerobic conditions, and identified…
…animals underwent ART interruption 3 weeks after the last N-803 dose and/or CD8 reconstitution. SIV reactivation was monitored by plasma viremia and RNAscope analysis in lymph node samples. The size…
…ART + PH797804 at week 6 or 1 after infection. ART efficacy was evaluated by measuring viral loads and reservoirs. As primary endpoints for PH-797804 efficacy, we evaluated protein levels…
…(LN) biopsies underwent immunohistochemical staining. Median lifetime sexual partners was higher in TGW (53) vs. CW (3, p=0.006) and MSM (25, p=NS). Among TGW, mean age of initial gender dysphoria…
…TCID50 of 1X105. The cohort was monitored for five weeks with scheduled blood, colorectal (CR) biopsies, and lymph node (LN) collections. Total envelope and sub-genomic viral loads (VL) were measured…