…[3 male, 3 female]) followed by whole-body PET-MR imaging. Maximum and mean standardized uptake values (SUVmax/mean) were calculated for regions of interest (ROI) and compared across cohorts using non-parametric tests…
…nodes divided by non-burst-associated lineages. To characterize PWH diagnosed in the follow-up period who were ever members or descendants of a transmission burst, we then detected bursts within any sliding…
…anti-CD4R1 fragment radiolabeled with Copper-64 revealed substantial uptake in the gut of healthy animals and reduced uptake following SIV infection. The probe uptake in the clusters of lymph nodes and…
…RNA copy numbers determined by RT PCR. Measureable Tat- and Rev-associated HIV RNA were assumed to represent active transcription of HIV proviral DNA. Results: The highest frequency of CD4 T…
…Cancer Specimen Resource (ACSR) provided 26 post mortem tissues from three HIV+/ART+ patients with no detectable viral load. Two died from metastatic lymphoma (Pt02, Pt04), and one from lung cancer…
…conditions. We now aim to validate these biomarkers in CD4+ T cells from people with HIV (PWH) and investigate their tissue specificity. Methods We collected lymph nodes, spleen, and liver…
…reservoir tissues of a primate model using a novel approach to mass spectrometry imaging (MSI). Methods: Reservoir tissues (GALT, lymph nodes, brain, testes) were removed at necropsy from an uninfected…
Lymph nodes (LN) which are the sentinels of the immune system, are the site where lymphocytes engage cognate antigen and become activated. How antigen localizes to the lymph node and is “seen”…
…selectively activate CD4+ T cells while minimizing NK and CD8+ activation. A combination with broadly neutralizing antibodies (bNAbs) which eliminate infected cells via cell-mediated cytotoxicity may enhance reservoir clearance and…
…nodes, adenoid, palatine and inguinal tonsil, soft palate and tongue. DNA was extracted and tested by qPCR for RRV, RLCV, and RFHV viral load. In situ hybridization targeting viral DNA…