…and CD4 memory populations. In results analyzed to date, pre-prime H3N2 HAI titers of controls (mean=1:55) did not differ from IL-21 treated animals (mean=1:100). Titers increased significantly (p=0.0018) in IL-21…
…3.5% FPR, geno2pheno), confirmed by phenotypic testing (TropChase). He had a 2nd relapse of AML in Jun/13 but after 8 courses of 5-azaC and 4 donor lymphocyte infusions CR was…
…determined the primary (>50%) risk group (based on transmission category) for each cluster. For large clusters (>25 persons) among men who have sex with men (MSM), we described size at…
…reservoir, while limiting treatment burden. Methods 17 RMs infected with barcoded SIVmac239m initiated ART on Day 42 post-infection and remained on ART for 55 weeks before starting two cycles of…
…FastTree2. Resulting phylogenies were rescaled to units of time using the R package ape. Next, we reconstructed the ancestral sequences at the nodes of the trees using MG94xREV codon model….
…blood CD4+ T-cells; (2) chronic infection, lymph node memory CD4+ T-cells; and (3) ART treated, peripheral blood memory CD4+ T-cells. Cells were enriched by bead separation, labeled with oligo-tagged antibodies,…
Background: The intestinal microbiome of men who have sex with men (MSM) is distinct as compared to non-MSM and is suggested to increase susceptibility to rectal HIV infection. Indeed, we…
…highly connected biomarkers identified central nodes such as TNF and IFNG, and KEGG pathway enrichment highlighted cytokine–cytokine receptor and Toll-like receptor signaling as key cross-compartment mechanisms (Figure). Conclusions BBB integrity…
…(LN) were collected throughout the study for flow cytometry and viral measurements. Spearman correlations were used to identify associations between viral control and over 30 immune parameters measured pre-ATI. Pre-ATI…
HIV reservoir persistence is an obstacle to cure. Elite controllers (ECs) suppress virus in the absence of anti-retroviral drugs. Immunologic mechanisms that lead to viral control and interventions that could…