…sexual networking apps used mainly by gay and bisexual men (GBM). Survey domains included sociodemographics, use of antibiotics as STI prophylaxis (including but not limited to doxyPEP), HIV/STI diagnosis history,…
…men. Other participants included 3 heterosexual cisgender men, 1 transgender woman and 2 cisgender women. Most (76.9%) completed college +/- advanced degrees. Behaviors that led to PEP initiation included: receptive…
HIV-1 Env glycoprotein is a trimer of heterodimeric gp120 and gp41 subunits that are produced from a gp160 precursor. The N terminus of gp160 contains a signal peptide (SP) which…
…move between PrEP and PEP and delivered by community health workers (CHW), would increase HIV biomedical prevention coverage among persons at risk in rural Sub-Saharan Africa. Methods: We conducted a…
Abacavir (ABC) binds non-covalently to the floor of the peptide-binding groove of HLA-B*57:01, altering the chemistry and shape of the antigen binding cleft. This allows previously untolerized self-peptides to be…
…a median 89 [IQR:73-103] months long interruption of a median 3 [IQR:1.7-5.9] years long HAART initiated within 10 weeks post-infection. Multiparametric flow cytometry assessed HIV-specific CD4 T cells producing IFNγ,…
…days; see figure). In contrast, the mean window period of the LAg-Avidity protocol is 106 days (95% CI: 76-146 days). We identified four 4 peptide pairs that outperformed the standard…
…Gag-specific T cells as well as the Gag-specific T cell receptor (TCR) repertoire in CPs on long-term ART and HICs. Methods We performed 10-day expansion assays using PBMCs from 5…
…cells can be targeted for CTL-mediated lysis using novel scDbs specific for HLA-E-bound epitopes. Methods: To validate HLA-E as a suitable scDb target, we used the previously characterized [i]M. tuberculosis[/i]-derived…
…early ART. In-depth analysis of lymph nodes during and after acute HIV-infection, may provide insight into the drivers of this inflammation. Methods: Samples were selected from a multi-centric Belgian cohort…