…the effects of N-803 on T cells and NK cells in peripheral blood (PBMC) and lymph nodes (LN). Methods Participants with AHI (Fiebig I-IV) were randomized in an open-label manner…
Background: Tumor necrosis factor (TNF) blockade in the treatment of autoimmune diseases has been linked to reactivation of tuberculosis (TB). Immune reconstitution inflammatory syndrome (IRIS) can complicate anti-retroviral therapy (ART)…
…from either anti-TIGIT and anti-PD-1 antibodies to the BiTE molecule. HIV-infected cell lines and primary cells isolated from lymph nodes (LN) of chronically SHIV-infected rhesus macaques were used as target…
The mammalian target of rapamycin (mTOR) is a key regulatory kinase that controls glucose metabolism and cell growth. Inhibition of mTOR has been linked with several immune regulatory functions that…
…suppression in lymph node (LN) tissues. Additionally, we investigated the cell subset that remained persistently HIV infected. We studied 16 hyperacute HIV-infected subjects who initiated therapy in Fiebig stage…
Determining which immunological mechanisms contribute to the development of broadly neutralizing antibodies (bNAbs) during HIV-1 infection is a goal to inform vaccine design. It is not understood if factors during…
…were then compared between groups (Wilcoxon rank sum statistics). The median (IQR) age of the patients was 36 (32,39) and the median (IQR) hemoglobin (Hb), CD4+ T cells and HIV…
…with significant expansion in the number of effector memory T-cells in PB (4.61- and 2.20-fold, respectively; p<0.01 for all these measures). Enhanced T-cell cycling was dependent on CTLA-4 inhibition, highlighting…
The mechanisms regulating the establishment/maintenance of HIV reservoirs are still to be determined, thus impeding the design of strategies limiting HIV persistence. Interleukin (IL)-10 is a key component of the…
…adaptive immune responses, including T regulatory cells, to selected gut bacteria that changed with HIV infection. Methodology: Based on our 16S rRNA sequencing from HIV+ and HIV- subjects we chose…