Background: HIV-1-specific broadly neutralizing antibodies (BnAbs), such as the membrane proximal external region (MPER) antibodies 2F5 and 4E10, contain long H chain complementarity determining region 3 (CDR-H3) which is encoded…
…test the binding affinity against 4E10 peptide as well as HIV-1 gp140 trimer. The neutralizing ability against HIV-1 isolates was tested by single-round Tat-regulated luciferase assay in TZM-bl cells. Also,…
…or protease inhibitor (PI)-based regimen to a raltegravir-based regimen reduces platelet reactivity and/or PMA. This study was designed as an investigator initiated, single-center, prospective randomized, open-label, blinded endpoint (PROBE) trial….
…IgM/IgG and neutralizing antibodies (nAb) titers were measured by immunofluorescence assay and by 50% plaque reduction neutralization test (PRNT50). Interferon-γ producing specific T-cells to MVA peptides was assessed by ELISpot…
…people living with HIV (PLHIV), increasing the potential for higher HIV-related morbidity, mortality, and transmission. This analysis aimed to describe IIT trends within PEPFAR-supported HIV programs from 2022 to 2024,…
…treatment coverage (Tx_CURR) and viral load suppression (VLS) to identify persistent disparities and inform targeted interventions. Methods We conducted a longitudinal analysis of quarterly PEPFAR Monitoring, Evaluation, and Reporting (MER)…
…testing, prevention and treatment from community to clinic and back – would reduce population-level HIV incidence. Methods We conducted a cluster randomized controlled trial in rural Kenya and Uganda. We…
…analyzed HIV testing and treatment outcomes reported quarterly to PEPFAR from 41 countries between 2016-2021. A descriptive trend analysis of testing and treatment outcomes from (January–March) 2016 through (April–June) 2021…
…were included. We describe infant and regimen characteristics at the start of ABC (including drug combinations and dosing) and outcomes up to 12 months after first use of ABC. Outcomes…
…ACE2 to yield ACE2-like catalytic activity – ACE2-like ‘abzymes’. Methods: To explore this hypothesis, we studied 67 patients hospitalized with COVID-19 who had disodium ethylenediaminetetraacetate (EDTA) anticoagulated plasma samples available,…