…are natural regulatory T cells (TREG) that migrate into the follicle and, similarly to TFH cells, up-regulate CXCR5, Bcl6 and PD1. Methods: Lymph node (LN) biopsies were obtained from SIV-infected…
…clock priors, inferring internal node ages (for each cluster ≥10 members). Reproductive numbers (R0) for individual large clusters were estimated using birth-death models. Most samples were from men (71%) with…
…of 11 viral barcodes were detected across the 4 animals, with mesenteric lymph node (mesLN), inguinal lymph nodes (ingLN), and spleen exhibiting viral barcode clonotype overlap with plasma virus. These…
…distinct viral reservoir characteristics in blood in such persons, however, viral reservoirs in lymphoid tissues from elite controllers remain largely unexplored. Methods Paired samples of mononuclear cells from blood (PBMC)…
The origin and extent of viral replication within the CNS during early HIV-1 infection remains unclear. We aimed to assess cerebral spinal fluid (CSF) for host cells actively transcribing virus…
…leads to reduced cell-associated HIV DNA in vitro and transient decreases in cell-associated HIV RNA in vivo. The impact of anti-CD30 therapy on tissue measures of HIV burden is unknown….
…plasma, semen and CSF viral load assays were used to detect HIV-1 RNA. The method for HIV DNA quantification in gut biopsies and lymph nodes was as follows: tissue samples from…
…tandem mass spectrometry. Phylogenetic analysis of CSF, plasma, rectal mucosa and cervical lymph node HIV variants was performed A man with HIV/AIDS [CD4: 6 cells/μL, HIV plasma viral load (VL):…
Repeat HIV testing during late pregnancy may identify women who seroconvert after an initial negative HIV test early in pregnancy, allowing these women to adopt lifelong antiretroviral therapy (ART) for…
Background: Tissue-resident memory T cells (TRM) are a recently described subset of memory T cells present in tissues. Although memory CD4+ T cells are a key target for HIV infection…