…T cell naïve and memory populations in blood and lymph nodes of HIV patients and healthy individuals. We analyzed peripheral blood samples of 36 HIV-1 infected patients (n=23 viremics/13=ART treated)…
…to SIV, and are thus, preferentially infected. Lymphocytes from Peripheral Blood Mononuclear Cells (PBMC), spleen, and Mesenteric Lymph Nodes (MLN) of SIV+, viremic rhesus macaques were isolated and simulated for…
…HLA-DR. HIV and CD32a RNA expression in tissue was measured by fluorescent in situ hybridization (FISH) in lymph node sections from 2 aviremic and 4 viremic HIV-infected patients. Ex vivo…
…in early infection, is limited. We thus investigated virus-host interaction in the lymph nodes (LNs) of rhesus macaques during early simian immunodeficiency virus (SIV) infection. Methods: Sixteen adult male macaques…
The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. Inhibitor of apoptosis protein antagonists (IAPa) reverse…
…either GM3 or DOPS)-coated block co-polymer core NPs and subcutaneously administered to Balb/c mice. Fluorescence and IVIS imaging of lymph nodes and spleen from NP-injected animals were performed on days…
…SIVagmsab-infected PTMs received the coformulated regimen starting from 48 days post-infection (dpi) and lasting for 11 months. Plasma viral loads were determined by qRT-PCR assay (detection limit: 30 copy/ml). CD4+…
Daily oral conventional ART, even in fixed dose combination forms, has inherent limitations such as patient adherence and disparate drug kinetics; both potentially impacting therapeutic outcomes. Oral dosing has also…
…103 (16%) of EPTB cases; with the highest proportions of confirmed cases in lymph nodes (30%), meninges (19%), abdomen (14%), joint/bones (11%), pleura (13%), and others (13%). Among patients with…
The ‘shock-and-kill’ HIV cure strategy involves latency reversal and immune-mediated clearance of infected cells. Our prior work showed systemic SIV latency reversal using the SMACm / cIAP antagonist AZD5582. Here,…