…RMs model, with a modest but measurable effect in reducing the levels of infected CD4+ T-cells. Ongoing NK assay to measure ADCC activity will provide mechanistic data. These findings inform…
…the sensitivity (Se) and negative predictive value (NPV), regarding only the classification made by that node. Results 1.033 patients were included, 597 (58%) were living with HIV. The median (Q1-Q3)…
…in the occipital lobe (interquartile range: [IQR] 0-4.6) to 659 cp/106 cells in lymph nodes (IQR 580-753), mean=98 cp/106 cells (IQR:23-132) across all tissues. We recovered 603 intact FL env…
…cases diagnosed in 2012). We then identified cases diagnosed through 2017 that were genetically linked to these clusters, representing cluster growth in the 5 years after prioritization. We performed Bayesian…
…over 20 km in New Delhi and formed one large network when accounting for social and spatial ties. Injection networks were highly dynamic (75% gained/lost a partner over a median…
…was first confirmed in an in vitro model of HIV latency. Then, freshly isolated blood and lymph node cells from ART-suppressed, HIV-infected individuals from the SCOPE cohort were stimulated with…
…of fully MHC-matched allogeneic HSCT to investigate the mechanism of cure in Timothy Brown. In this model, a reduced intensity conditioning (RIC) regimen consisting of chemotherapy, CD3 depletion, and total…
…T cell egress from LN resulted in a measurable decrease of SIV-DNA and -RNA content in LN Tfh cells in most treated animals as measured by RNAscope (p=0.02; n=6) and…
…cure. Methods CCR5 receptor-targeted lipid nanoparticles (M5-LNPs) encapsulating CRISPR-Cas9 and gRNA were formulated using microfluidics; untargeted C-LNPs served as controls. The RiboGreen assay determined the mRNA encapsulation efficiency. LNP size…
Background: Understanding the dynamics of HIV transmission may provide opportunities for public health interventions. Methodology: We inferred a partial local transmission network among 478 recently HIV infected persons and 170…