HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein, between capsid (CA) and spacer peptide 1 (SP1), leading to the production of…
…HIV-1 Gag peptide pool stimulation followed with IL-2/IFN-γ/TNF-α intracellular staining. Transcriptome analyses by RNA-seq were performed with purified human CD8 T cells to identify pathways and genes contributing to IFN-I-induced…
…(PWH) in ACTG A5370. Using flow cytometry, we evaluated changes in CD4+ and CD8+ T cell polyfunctional responses (?2) to HIV peptide pools by measuring intracellular expression of CD107a, IFN?,…
…isolates. Methods: A panel of 4-1BB costimulated CAR T cells expressing 18 distinct bNAb-based CARs were generated against all well-characterized epitopes on HIV Env: V1/V2 apex, V3-glycan supersite, CD4 binding…
…(TCF-1, Tbet), effector molecules (Granzyme B, Perforin), and surface proteins (PD-1, CD127, CCR7). Proliferation of the tetramer+ population was measured after 6-day in vitro peptide stimulation of CellTraceViolet (CTV)-labeled cells….
…mononuclear cells (PBMC) were measured by real-time PCR. Flow cytometry was used to investigate CD4 T cells for 1) co-expression of PD1 with IA (ICOS, CD38, Ki67 and HLA-DR); 2)…
T cell-based therapeutic vaccination is a potential approach to achieving durable control of HIV. It is assumed, but has not been thoroughly evaluated, that inclusion of Env antigens in a…
…total of 407 participants (277 PLWH and 130 controls) were included; 36% were female. Median age was 55 (interquartile range (IQR): 52-60) years and median duration of ART was 16…
Background: Cervical cancer is the second most reported cancer (13%) among women aged 15-49 years old in Ethiopia. Human papilloma virus (HPV) types 16 and 18 are associated with about…
…$25/year. Methods The UNAIDS Spectrum model was used to estimate HIV incidence in countries included/excluded from voluntary licenses for LEN and CAB-LA. Worldwide sales of CAB-LA in 2024 were combined with…