…baseline and week 8. Validated liquid chromatography-tandem mass spectrometry (‘LC-MS/MS) was used to quantify DOR concentrations, and HIV-1 RNA was determined by real-time PCR (Abbott). Data are presented as median…
…like central memory (Tcm), which harbor latent provirus. Tissue-specific sources include lymphoid tissues (lymph nodes, spleen, and gut-associated lymphoid tissue), where virus can persist despite ART. The central nervous system…
…SIV infection accelerated progression to AIDS and death. Its mechanism and the consequences of exogenous IFN-I treatment during acute infection are unknown. Methodology: 6 rhesus macaques (RMs) received IFN-1ant and…
…1st dose, ~50% of RT profiles achieved ME; ~88% achieved it 24hr post-dose. No regimen achieves ME in CT; ~70% of CT profiles achieved EC90 at 24hr post-dose. ME was…
…populations, such as men who have sex with men (MSM). Methods We conducted a network-based online survey among MSM and transgender women (TGW) in Baltimore, MD that included PrEP use…
…the free base form, and metabolites including AT-273, the guanosine nucleoside metabolite, a surrogate for intracellular AT-9010. AT-527 was well tolerated with no discontinuations, serious AEs, clinically significant changes in…
…Understanding the mechanisms behind durably containing HIV replication may guide new strategies towards HIV remission. Here, we used the well-established model of SIV-infected rhesus macaques (RMs) to investigate the features…
…However, whether these latently infected cells are formed directly after integration or following a phase of productive infection remains unclear. In this study, we addressed this question in SIV-infected rhesus…
…T cell function and metabolism by Fluidigm Biomark assay. Single-cell sorting of U, L, and P cells (62 cells per group) was performed using cells from one tonsil donor for…
…by separate administration of the DNA and Protein components in contralateral sites. Female rhesus macaques (20 animals/group) were immunized with a 6-valent vaccine including DNA plasmids expressing membrane-anchored gp145 Env…