…Kenyan patients with non-B subtypes failing first line therapy with neviripine or efavirenz. Methodology: RV288 is a multi-center PEPFAR Basic Program Evaluation that is being conducted in Kenya, Tanzania, Uganda…
…phage display library composed of 39 amino acid peptides covering the complete genomes of SARS-CoV-2 and the six other CoVs known to infect humans. Using samples from patients with confirmed…
…of treatment options to WHO recommended treatment regimens at two IHVN PEPFAR supported sites in Abuja. Methodology: Plasma samples from patients who failed LPV/r and ATV/r- based second-line regimens from…
…regimen) × TE interaction on reservoir metrics adjusting for clinical/ART history covariates. Observed margins (real regimen mix) and counterfactual margins (covariates set to isolate each ARV class and assess pure…
…of CD4+/IL22+ and CD4+/IL-17+ T-cells in PBMC, rectal and lymph node mononuclear cells and of central memory CD4+ T cells in blood was also observed in the ART+p38 inhibitor group…
…for primary effusion lymphoma (PEL) or metastatic adenocarcinoma; both were on effective ART with HIV RNA < 50 c/ml. Tissue samples (lung, mediastinal lymph node, spleen, testes, liver, and neoplastic…
…(median nadir:743 cells/µl; median SIV RNA set-point:3,760 copies/ml. 4/5 had a protective haplotype). The remaining five showed features of CP with CD4 T counts <500 (median nadir:177 cells/µl; median SIV-RNA…
…aimed to increase antibody responses and levels of somatic hypermutation. Safety information is solicited throughout a period of 18 months. Serological assays are performed, as well as lymph node fine…
…1). Participant #2 proviruses often contained large deletions (88% of all defects), whereas viral genomes from participant #1 displayed equally hypermutations (39%) or large deletions (42%). Intact HIV genomes represented…
…sequencing, we isolated intracellular HIV-1 genomes derived from defined subsets of CD4+ T cells (central (CM)-, transitional (TM)-, and effector (EM)-memory) from peripheral blood and lymph node tissue. Samples were…