…levels, followed by a decline to undetectable levels in peripheral blood, lymph nodes, and colorectal tissue for >8 weeks prior to ART discontinuation. Autologous cellular immune responses were minimal and…
…and 2NRTIs is the new standard regimen. However, the influence of these drugs on the recovery of immune cells in blood and lymph node (LN) tissue has not been well…
…tissue (spleen, lymph node, gut) from virally suppressed PWH (n=6; undetectable plasma viral load for a median of 3.41 years) were provided by the National NeuroAIDS Tissue Consortium. HIV LTRs…
…a normal peripheral CD4 count is obtained. The immunologic and clinical characteristics of this clinical phenotype remain undefined. Methodology: We evaluated the associations of the CD4/CD8 ratio with 1) maturational…
…reservoir size in IciStem patients 5 and 11 was investigated. SCT was performed using HLA-matched CCR5Δ32 donors. Before SCT we performed: 1) Phenotypic and genotypic co-receptor tropism analysis 2) Quantification of…
…T cell losses occurring in many lymphoid tissues like tonsil and spleen. Methodology: Human lymphoid aggregated cultures (HLACs) were prepared using tonsil and spleen tissue; lymph nodes from consenting HIV-infected…
Background Following acute HIV infection, proviral DNA integrates into the genome and becomes latent. However, while the epigenetic mechanisms silencing proviral DNA likely present druggable targets for a cure, they…
…characterized by a cascade of inflammatory cytokines followed by a negative feedback loop of anti-inflammatory cytokines, such as IL10, in order to reestablish homeostasis. Interestingly, viruses have evolved mechanisms that…
…analytic treatment interruption (ATI). Methods RV550 is a 3-step clinical trial that enrolled participants in AHI. In Step 1, participants received ART alone or ART + N-803 (6 mcg/kg every…
The ability of HIV to replicate in secondary lymphoid organs (SLO) and disrupt lymph node (LN) architecture are considered main determinants of disease progression. HIV-2+ individuals feature slow rate of…