…into 19 transmission clusters (median cluster size = 3). One major transmission cluster involved 92 cases (Fig.1: Orange nodes). Fig.1: Network of transmission clusters identified by Global Hepatitis Outbreak and…
…T cell response, reservoirs, and lymph node localization of cytolytic CD8 T cells were interrogated longitudinally at key time points of the study. We show that CD40L adjuvated DNA/MVA vaccine…
…their activation and in vitro HIV-1 infection. We performed phenotype analyzes and functional studies using CD4+ T cells from peripheral blood and lymph nodes from cohorts of HIV-1 infected subjects…
…distinct viral reservoir characteristics in blood in such persons, however, viral reservoirs in lymphoid tissues from elite controllers remain largely unexplored. Methods Paired samples of mononuclear cells from blood (PBMC)…
…8 humanized hBLT-mice were injected with HSC-derived DCs cultured in media (MED), gag peptides alone (GAG) or in combination with 2´-3´-c-AMP and Poly-I:C TBK-1 adjuvants (GAG-ADJ) and infected intravenously with…
…sacrificed in chronic stage disease. Animals had colorectal and lymph node biopsies prior to infection, were followed longitudinally by blood collection and full tissue collections were performed at necropsy. Phenotypic…
…evaluated over time. Combination of in vivo imaging techniques (near infrared imaging, probe-based confocal laser endomicroscopy and two-photon microscopy) allowed the identification of the lymph nodes of interest that had…
…in blood. Methods: To characterize the unique populations in LN, we obtained LN samples from rhesus macaques during early chronic SIV infection (D42 post-infection) and performed flow cytometry, scRNA-seq and…
…routes between the HIV epidemics in the United States, Mexico and Central America, including Guatemala, Belize, Honduras, El Salvador, Nicaragua and Panama. Methods: We analyzed 7943 HIV-1 pol sequences collected…
…were estimated as “acute” with recent HIV transmissions. The median estimates of R were 0.7–1.6. The V1C5-based informativeness of R estimates differed across sub-epidemics. The median peak duration of viral…