…Next, we subsampled based on node influence. Expected Force (ExF) computes spreading power of individual nodes via adopting a relative influence of different walk and walk lengths based on local…
…B peptides were decreased and there were no differences in the response to gag peptides. At necropsy (~20 weeks post-infection), VRC01-Rh-α4β7-treated macaques had significantly more IFNγ-producing T cells in the…
…study aimed to determine the potential role of immune checkpoint (IC)/IC-Ligand (IC-L) interactions on HIV transcription in lymph node (LN) microenvironment. To address this issue, we assessed the expression of…
…two-sided rank-sum, signed-rank tests and Spearman correlations (α=0.05). Of 44 participants, 93% were male, 50% white non-Hispanic, median age 48 years, CD4+ T-cell count 588 cells/mm…3…. Week median (IQR) number…
…TGFβ and TNFα were measured by immunohistochemistry. In AHI, no differences were observed between the groups. At wk48, in LN, the frequencies of resting memory (RM) B cells (CD21+CD27+IgG+CD20+) were…
…Methods Lymph node (LN) tissue from 6 people with HIV (PWH; n=3 undetectable, n=3 viremic) were obtained from the Pathology Anatomy Unit from Hospital Universitario La Princesa. LNs from people…
…Study participants included 10 young women (16 to 24 years old) who initiated therapy in Fiebig stages I-V, and 10 age matched women who started therapy after Fiebig V. Excisional…
Natural killer cells (NKs) play an essential role in antiviral immunity; however, their function in Lymph nodes (LN) during chronic HIV/SIV infection is not fully elucidated. LN follicles constitute major…
…nodes (LN) are a primary site of HIV replication, and studying the CD8 T cell response at this level may provide additional insights. Methods We performed an in-depth characterization of…
…(PLWH) and SIV-infected rhesus macaques (RM). Methods: Inguinal LN frozen in OCT from 7 PLWH (3 female; median age 42y; median viral load 4.35log10; median CD4 706) and 5 RM…