…ferritin nanoparticles. A single boost elicited antibodies with preferential binding to the glycopeptide versus the aglycone peptide. A second boost increased glycopeptide binding, but also induced V3 peptide-specific antibodies. Boosting…
…MHC molecules covalently-tethered to a virus-derived peptide enabling delivery of TCR-specific and costimulatory signals to antigen-specific T cells. We hypothesized that synTac-activation of virus-specific effector-memory CD8+ T cells would selectively…
…Å resolution cryo-EM structure of the active Vps4 hexamer in complex with its cofactor Vta1, ADP·BeFx, and an ESCRT-III substrate peptide. Five Vps4 subunits form a helix, with interfaces between…
…of these responses. Methods We evaluated HIV-specific CD8+ T cell responses of 6 PTCs, in comparison to 6 previously ART-treated spontaneous controllers (TCs) and 11 non-controllers (NCs), both pre- and…
Therapeutic HIV immunisation followed by latency reversal has been suggested as a strategy to achieve a functional cure for HIV. The efficacy of a therapeutic peptide vaccine to improve antiviral…
…phage were immunoprecipitated and after two rounds of enrichment, were deep sequenced to quantify enriched viral peptides. Separately, unbiased metagenomic next-generation sequencing (mNGS) of total CSF RNA was performed to…
…is to understand the R5 resistance pathway in a comprehensive way based on envelope sequence data. Methodology: We use population genetic, coevolutionary, recombination, positive selection and structural analysis to analyse…
…with anti-TIGIT (median fold change, FC compared to isotype controls 1.75x) and anti-CTLA-4 (median FC 1.38x) in HIV-specific CD4+ T cells. We also observed increased frequency of cells expressing IL-2…
…marked by BCL-2, cytotoxic gene overexpression and metabolic quiescence. Here, we demonstrate metabolic quiescence and low oxidative stress as a mechanism of resistance in authentic reservoir clones (ARCs). Methods ARCs…
Geosocial networking (GSN) smartphone applications (apps) are becoming the main venue for sexual encounters among Brazilian men who have sex with men (MSM). As HIV infection risk has been increasing…