…effective (IC50<100pM) against all variant tested. Methods A catalytically inactivated ACE2 peptidase domain was fused to the N-terminal end of a human IgG1 Fc, either directly or via a flexible…
…during the DHS, including 1,009 adults at least 40 years of age, and performed high-throughput HCV viremia testing using the Abbott m2000 instrument (Abbott Molecular, Des Plaines, IL). The Abbott…
The American College of Cardiology suggested physicians should only measure troponin and brain natriuretic peptide (BNP) if myocardial infarction or heart failure were suspected in people with COVID-19. We aimed…
…immune exhaustion (PD-1, TIM-3, LAG-3) and generalized markers of inflammation (D-dimer, IL-6). Outcome measures included time to trial primary endpoint and time to plasma viral load rebound on stopping ART….
…approval date. We aim to describe real world metabolic outcomes in PWH using tirzepatide for weight loss or diabetes treatment. Methods Included were PWH seen at the UCSD Owen clinic…
…LIPID MAPS and LIPID MAPS) were searched to provide a putative identification of the MFs. MF presumed to be small peptides and lipids (triglycerides, glycosphingolipids, vitamin D metabolites) dominated the…
…Venetoclax, and co-cultured with HIV Pepmix expanded, CD8 T Cells, in the presence of ART. The CD8-negative target cells were analyzed by flow cytometry to measure cell death by Live/Dead…
…users of tirzepatide using a longitudinal quasi-experimental pre-post study design. Both outcomes were estimated using multivariable linear mixed models of the trajectory of the outcome, and adjusted for age, sex,…
Background Glucagon-like peptide-1 receptor agonists (GLP-1RA) are used to treat diabetes and obesity in people with HIV (PWH). It has been hypothesized that GLP-1RA medications may reduce addictive behaviors by modulating neural reward…
…packages in R. Results: The median age of participants was 31 years and median HIV plasma viral load was 4.4 log10 copies/ml with a CD4 count of 400 cells/ml. ART…