…and tissue glucose metabolism in African Green Monkeys (AGMs) and Rhesus Macaques (RMs) during the early days following SIV inoculation, using 18F-Fluordeoxyglucose (FDG)-Positron Emission Tomography (PET)Computed Tomography (CT). Methods: Six…
…TAF/FTC, n=1. Median (and interquartile range) IQ values for the INSTIs in PBMCs, LN, ileum and rectum are given in the Table. In PBMCs, the median IQ values for DTG,…
…ART. Plasma viral load and immunophenotypic analyses on PBMCs, lymph nodes and gut were performed throughout the study. RNASeq analyses were performed at days 0, 3 and 7 post 1st…
…subset of animals (n=6) to assess viral rebound. Blood and tissue were collected throughout the study for flow cytometry and viral measurements. For whole-body ImmunoPET, macaques were infused with 68Ga-labeled…
…and lymph nodes was achieved. PVLs peaked at 107 viral RNA copies/mL at 10 dpi, followed by a 4-log decrease by 28 dpi. PVLs were lower compared to SIV-infected historical AGM…
…CD4 T cells was unchanged, caspase-3 expression was elevated in ILC1 (mean caspase-3=12%), ILC2 (mean caspase-3=24%), and ILC3 (mean caspase-3=4%) subsets in acutely infected animals when compared to caspase-3 expression…
…on Delta strain SARS-CoV-2 infection in pigtailed macaques (PTMs). Methods Control group (n=3, 2M, 1F) PTMs were sampled pre- and post-SARS-CoV-2 infection until euthanasia and necropsy (Nx) at day 30…
…plasma and CSF were determined using a validated LC-MS method. Unbound DOR concentrations were determined using Rapid Equilibrium Dialysis. HIV RNA was measured in plasma and CSF by RT-PCR (LLQ…
…the latent viral reservoirs persist in these individuals. In a recently described nonhuman primate model of elite control, pigtail macaques (PTMs) are infected with a variant of SIVmac239 (termed ?GY)…
…days of culture by measurement of p24 in culture supernatants. TFV, TAF and TFV-diphosphate (TFV-DP) concentrations were measured in tissue, culture supernatants and dosing and washing solutions using LC-MS methods….