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1277 Results
Background The public health impact of data to care (D2C) programs has been limited by difficulty identifying and reaching out-of-care persons with HIV (PWH) using HIV surveillance data alone but may be improved by incorporating other data sources. Methods We compared the following sources used for D2C in King County, WA during 9/2023-9/2024: the enhanced HIV/AIDS…
Background Despite the availability of oral HIV pre-exposure prophylaxis (PrEP), gaps remain in reaching the UNAIDS target of 21.2 million people on PrEP by the end of 2025 and reducing HIV incidence. The U.S. President’s Emergency plan for AIDS Relief (PEPFAR) is leading the rollout of long-acting PrEP in high-burden settings, which provides an opportunity…
Background Oral PrEP uptake remains limited in Latin America, even as new HIV diagnoses continue to rise, especially among sexual and gender minorities (SGM). Previous research has highlighted a preference for long-acting PrEP in the region. With the approval of long-acting injectable cabotegravir and recent results of lenacapravir for PrEP, understanding PrEP preferences is vital…
Background The CDC recently issued guidelines recommending doxycycline post-exposure prophylaxis (doxyPEP) for men who have sex with men (MSM) who have had a bacterial sexually transmitted infection (bSTI) in the past year. However, this strategy remains underutilized among some groups. The primary objective of this study was to explore doxyPEP use, prescription within participants’ primary…
Background Understanding and identifying HIV-1 neutralization escape requires isolating envelopes that have undergone antibody selection pressure. However, recombinant artifacts are generated during bulk reverse transcription (RT) and subsequent PCR, which can affect neutralization phenotype. To avoid this, amplification from a single genome is essential. We addressed this by developing a novel droplet-based one step RT-PCR…
Background In 2015, the CDC estimated that 1.2 million Americans could benefit from PrEP; however, this may now be outdated, particularly given ambitious CDC HIV elimination goals. Methods Using responses to the most recent suitable NHANES survey (2015/16), including respondent age and sex, number and sex of sexual partners, number of times having sex, condom…
Background The Ending the HIV Epidemic (EHE) program was launched in 2019 with the goal of reducing HIV transmission in the US by 75% by 2025 and 90% by 2030. Men who have sex with men (MSM) are a priority population in this effort. Our objective was to model the impact of improvements across the HIV…
Background Despite scale-up of HIV testing, ART, and pre-exposure prophylaxis (PrEP), there continue to be over 140,000 new HIV infections in South Africa each year. Our objective was to estimate the optimal distribution of resources to HIV testing, ART, and PrEP to reduce HIV transmission in South Africa. Methods We developed an optimization model to…
Background The Centers for Disease Control and Prevention (CDC) recommends routine HIV screening of persons aged 13-64 years and additional testing for those with exposure risk or symptoms. All positive HIV antigen/antibody (Ag/Ab) immunoassay results should be confirmed with HIV antibody differentiation and HIV RNA testing to resolve conflicting results. Understanding the performance and efficiency…
Background Low-barrier care (LBC) improves viral suppression (VS) among persons with HIV (PWH) who have complex needs. We extend prior analyses of LBC effectiveness and identify patient characteristics associated with greater benefit. Methods This retrospective cohort analysis included PWH enrolled in the Max Clinic in Seattle, WA from Dec 2014–Dec 2023 who had ≥6 months…