WASHINGTON STATE CONVENTION CENTER

Seattle, Washington
March 4–7, 2019

 

Conference Dates and Location: 
March 4–7, 2018 | Boston, Massachusetts
Abstract Number: 
88

RAPID REDUCTION IN HIV DIAGNOSES AFTER TARGETED PrEP IMPLEMENTATION IN NSW, AUSTRALIA

Author(s): 

Andrew Grulich1, Rebecca J. Guy1, Janaki Amin2, Heather-Marie Schmidt3, Christine Selvey3, Jo Holden3, Karen Price4, Robert Finlayson5, Mark Bloch6, Iryna Zablotska1, Fengyi Jin1, David Smith7, Anna McNulty8, David A. Cooper1

1University of New South Wales, Sydney, NSW, Australia,2Macquarie University, North Ryde, NSW, Australia,3New South Wales Ministry of Health, Sydney, NSW, Australia,4ACON, Sydney, NSW, Australia,5Taylor Square Private Clinic, Sydney, NSW, Australia,6Holdsworth House Medical Practice, Sydney, NSW, Australia,7North Coast HIV Sexual Health Services, Lismore, NSW, Australia,8Sydney Sexual Health Centre, Sydney, NSW, Australia

Abstract Body: 

Randomized trials of pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) have reported efficacy of more than 85%. Modelling predicts PrEP will have greatest population-level efficacy if rapidly targeted, with high coverage, to those at high risk. In New South Wales (NSW), more than 80% of HIV diagnoses occur in MSM. Despite substantial increases in testing and treatment since 2012, and the state approaching the UNAIDS 90/90/90 targets, annual HIV diagnoses varied little over the decade to 2016.

The expanded PrEP Implementation in Communities in NSW study (EPIC-NSW) is an open-label implementation study of the use of co-formulated TDF/FTC to prevent HIV. Commencing March 1 2016, we aimed to recruit all estimated 3700 MSM at high-risk of HIV in NSW by end 2016, in over 20 clinics across the state. High-risk eligibility criteria were based on local epidemiologic data. Co-primary outcomes of the study are (a) HIV incidence among study participants, collected by electronic data capture from clinic data management systems and (b) state-wide HIV diagnoses in MSM, utilizing NSW Ministry of Health HIV surveillance data. HIV surveillance data were reported as (a) all diagnoses and (b) early infection, defined as likely HIV infection in the last 12 months, based on HIV testing history and/or clinical and/or laboratory diagnosis of recent infection.

The initial target of 3700 high-risk MSM was reached in October 2016, with an average monthly recruitment of 499 (range: 442-555). Recruitment is continuing (currently 7293). By September 2017 only one HIV seroconversion in a study participant was documented. In the first half-year of 2017 there were 101 HIV diagnoses in MSM in NSW, 35% lower than the 156 diagnoses in the half-year immediately prior to commencement of recruitment (June-Dec 2015). This was the lowest half-yearly number of HIV diagnoses in MSM since HIV surveillance commenced in NSW in 1985. Early HIV infections in MSM declined from 82 to 46, a 44% decrease.

The high-level, targeted and rapid roll-out of PrEP in NSW led to a 35% decline in state-wide HIV diagnoses in MSM, and a 44% decline in early HIV infections in MSM, to levels unprecedented since the beginning of the HIV epidemic. This was achieved less than one year after the target recruitment was reached. In a concentrated epidemic with high testing and treatment coverage, PrEP scale up led to a rapid decline in HIV transmission at the population level.

Session Number: 
O-07
Session Title: 
OF MICE, MONKEYS, AND MEN: PrEP FROM PRECLINICAL TO POPULATION LEVEL IMPACT
Presenting Author: 
Andrew Grulich
Presenter Institution: 
University of New South Wales