Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.

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Search Results

1277 Results

625 – Number and Effectiveness of Antihypertensives Are Associated With Cognitive Performance in PWH

Background People with HIV (PWH) experience age-related health problems, including cardiovascular disease and cognitive decline. Some medications used to treat hypertension exhibit anticholinergic properties. This study investigated the effects of cognitive performance on antihypertensive use and mean arterial pressure (MAP) in hypertensive PWH and people without HIV (PWoH), focusing on whether worsening cognitive function influenced…

608 – T-Cell Receptor Repertoire and Cognitive Performance in People With HIV

Background The T cell receptor repertoire (TCR) plays a key role in immune surveillance and regulating inflammation. Alterations in TCR are linked to cognitive decline in Alzheimer’s Disease. In animal models, TCR affects neuronal plasticity and memory through T helper 2-mediated responses. By disrupting immune homeostasis, HIV can affect TCR and cognition. We assessed whether…

596 – Cannabis Use Is Associated With Reduced Brain Integrity in Persons With HIV

Background Cannabis (CB) use is increasing nationwide due to legal changes and commercialization. People with HIV (PWH) are more likely to use CB versus people without HIV (PWoH). Data on the effects of CB use on brain structure and cognition in PWH are mixed, with few studies including measures of structural brain integrity. Methods In…

623 – Hypertension: A Major Factor in Low Verbal Fluency Among People Aged 50+ Living With HIV in Senegal

Background Decline in verbal fluency, observed both in aging and HIV infection, is associated with reduced quality of life. The association of cardiometabolic diseases with verbal fluency is well described in Western Countries, not in Sub-Saharan Africa, especially in older people living with HIV (PLWH). This study aims to identify the factors associated with verbal…

603 – Cognitive Intra-Individual Variability Predicts IADL Function in the Women’s Interagency HIV Study

Background Cognitive intra-individual variability (IIV) refers to the variation observed in cognitive performance when various cognitive tests are administered within the same person (i.e., dispersion). In people with HIV, greater cognitive IIV has been associated with poorer cognitive performance and decline over time, cortical brain atrophy, and increased mortality risk. In this study, we calculated…

631 – HIV-Infected Microglia Drive Transcriptional and Metabolic Changes in Complex Human Brain Organoids

Background HIV enters the central nervous system early after infection which can result in HIV-associated neurocognitive disorder (HAND), affecting as many as 50% of people living with HIV (PWH). HIV-induced neuroinflammation plays a critical role in HAND. Here, we investigated the impact of HIV infection on brain inflammation and metabolism using an advanced 3D human brain…

620 – No Impact on the CNS After Switching to Dolutegravir/Lamivudine From a 3-Drug Regimen

Background Dual-drug therapy with dolutegravir/lamivudine (DTG/3TC) is effective in achieving viral suppression in the blood, but its impact on HIV infection in the central nervous system (CNS) remains insufficiently explored. In this study, we aimed to investigate its effect in the CNS through assessment of cerebrospinal fluid (CSF) in individuals switching to DTG/3TC from a…

613 – Epigenetic Modifications Predictive of Cognitive Frailty in Cocaine-Using People Living With HIV

Background People living with HIV (PLWH) are disproportionately burdened by neurocognitive impairment (NCI) and physical frailty. Cognitive frailty, the combination of both, results in poorer outcomes than physical frailty or NCI alone. While epigenetic modifications are linked to each of these conditions separately, cognitive frailty remains understudied, and HIV and cocaine use may worsen outcomes.…

627 – HIV Transcripts in Blood May Identify Patients at Lower Risk of Brain Injury in Cure Research

Background Suppressed HIV patients’ PBMC have residual cell associated HIV-1 RNA transcripts (HRT). Elevated HRT, despite ART, associate with viral blips and with brain injury. Most cure studies aim to reduce HIV DNA reservoir but may require initial viral reactivation, risking brain injury from viral blips due to reservoir activity. Under ART, blips are believed…

617 – High Anticholinergic Burden and Poor Sleep Quality in People With HIV

Background Anticholinergic burden (ACB) and related effects affect the quality of life of people with HIV (PWH) through a broad range of mechanisms: e.g., increased risk of falls, pleomorphic symptoms, and cognitive decline. To date, no study has investigated whether ACB influences also the quality of sleep (SQ) in PWH. Methods Cross-sectional single-centre multidimensional assessment…