Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
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1277 Results
Background The advent of long-acting (LA) injectable ART has transformed the conceptualization of ART. However, there is a need for Real World Data on the impact of this novel approach on peripheral inflammation. The aim of this study was to investigate the dynamic changes in monocyte/macrophage subsets and their soluble activation markers in PLWH switching to…
Background CMV infection is a driver of immune activation and senescence, with greater impact in the setting of HIV-1 co-infection, where it contributes to CD8 T cell expansion and low CD4/CD8 T cell ratios. CMV replication occurs primarily in people with HIV-1 (PWH) with low blood CD4+ T cell counts, but occult CMV replication may…
Background A virulent HIV-1 subtype B clade (VB) first reported in 2022 (Wymant et al. 2022), is linked to higher viral loads (VL), faster CD4+ T-cell decline, and greater transmissibility. This presents significant challenges for clinical management due to its faster disease progression. The study aims to elucidate the effects of VB on clinical outcomes…
Background Broadly neutralizing antibodies (bNAbs) provide a useful tool for HIV cure strategies because of their ability to target conserved regions on the envelope (Env) protein in the context of both virions and infected cells. Multiple clinical trials of single and combination bNAb therapies in people living with HIV demonstrated transient viral suppression after infusion.…
Background Antiretroviral therapy (ART) controls viral replication in people with HIV (PWH), but viral reservoirs (VR) persist and represent a cause for the occurrence of age-related comorbidities, e.g. cardiovascular disease (CVD). We demonstrated that retinoic acid (RA, a vitamin A derivative) increases HIV-1 outgrowth from VR and that microbiota components (e.g., Staphylococcus aureus) promote ALDH…
Background HIV-1 Exceptional Elite Controllers (EEC) maintain undetectable viremia and halt disease progression more than 20 years after infection in the absence of treatment and may be considered as functionally cured. However, loss of control in these individuals is unknown. In this study we performed a detailed, longitudinal characterisation of the HIV-1 reservoir, viral evolution…
Background Nutrient metabolism influences HIV-1 replication, immunity, and chronic inflammation but is difficult to target therapeutically. We hypothesized that regulating metabolism via caloric restriction (CR), a safe, anti-aging modality with anti-inflammatory effects could improve SIV disease outcome in rhesus macaques (RMs). Methods Healthy, non-obese, adult male and female RMs (n=6) were experimentally restricted to consume…
Background In the gut, early HIV-1 (HIV) infection is associated with high HIV replication, CD4 T cell death, and microbial translocation. Among HIV proteins, Vpr remains enigmatic. In vitro, Vpr is linked to cell cycle arrest, DNA damage, apoptosis, and HIV replication in myeloid cells. Consistent Vpr phenotypes are lacking in CD4 T cells (CD4…
Background Despite antiretroviral therapy (ART), people with HIV (PWH) experience higher rates of morbidity and mortality than people without HIV (PWoH), which may be driven by chronic inflammation due to persistent virus. Inflammasome activation leading to proinflammatory cytokine production may be a major driver of this risk. Identification of genes associated with signaling cytokines could…
Background Viral diversification complicates immune-based cure strategies. SIV-infected Rhesus macaques (RMs) treated with antiretroviral therapy (ART) provide insights into viral dynamics and reservoir persistence in people with HIV-1. We previously described a shift in the composition of infected cell populations during ART, with recently infected cells harboring mutated proviruses decaying more rapidly, and ancestral variants…