Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
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1277 Results
Background Natural Killer (NK) cells are underappreciated regulators of the antibody response to infection. In mice, NK cells can kill T follicular helper cells which decreases somatic hypermutation and vaccine response. In the context of HIV, dysfunctional NK cells are associated with broadly neutralizing antibodies. Understanding the temporal immune factors that influence breadth is an…
Background Chronologic aging has been reported to impair antibody responses to influenza (flu) vaccination with greater impairment in PWH occurring at a younger age than in people without HIV (PWoH). High-dose (HD) vaccine, with four times more antigen than standard-dose (SD), is recommended for people ages ≥65 years to improve effectiveness but has not been…
Background Nonsuppressible viremia (NSV) represent a subset of individuals with persistent low-level viremia due to a hyperactive HIV reservoir. Little is known about whether persistent antigenemia during NSV can induce a stronger immune response. Autologous neutralizing antibodies (aNAb) represent a key adaptive immune response for viral control and HIV rebound during treatment interruption has been…
Background In May 2022, WHO considered the outbreak of mpox infection as a public health emergency of international concern (PHEIC). Vaccination was recommended for people living with HIV (PWH) and users of pre-exposure prophylaxis (PrEP). The need to vaccinate the population at risk worldwide, mainly PWH and PrEP users has increased. The immune response generated…
Background Background Despite the success of antiretroviral therapy in controlling HIV-1 replication, achieving a cure remains a significant challenge. One obstacle to blocking HIV-1 replication is the efficient cell-to-cell transmission (C-CT) of HIV-1, which is highly resistant to broadly neutralizing antibodies (bnAbs). Here, we studied the effects of immune-based strategies, including antibody-dependent cellular cytotoxicity (ADCC)…
Background For most people with HIV (PWH) on antiretroviral therapy (ART), cessation of ART results in rapid rebound of viremia. However, in rare individuals, called post-treatment controllers (PTCs), HIV is controlled through poorly understood mechanisms. The objective of this study was to leverage multiomics single-cell sequencing approaches to assess the extent to which the transcriptomic and epigenetic features…
Background People living with HIV (PLWH) have a higher risk of herpes zoster (HZ) reactivation and postherpetic neuralgia (PHN) compared to general population. Our study aims to evaluate prevalence of HZ reactivation and PHN after vaccination with recombinant vaccine in a population living with HIV, and to identify risk factors associated with recurrence. Methods We…
Background There is a need to design novel HIV-1 vaccine candidates that could elicit broadly neutralizing antibodies (bnAbs) and that reflect currently circulating viruses. Here we tested a subtype B envelope (Env) consensus designed in silico with shortened hypervariable loops and a native B Env to compare their Ab binding and neutralizing responses in rabbits. Methods A…
Background Despite early antiretroviral treatment (ART) initiation, persistent immunological alterations have been described in individuals treated during acute HIV infection (AHI). We performed longitudinal phenotypic and transcriptional profiling of peripheral blood mononuclear cells (PBMCs) after AHI to better understand the impact of early ART on cellular immune responses. Methods We conducted 26-color flow cytometry on…
Background Virus-specific CD8+ T cells are important for controlling chronic viral infections such as HIV. However, it remains unclear how the cumulative duration of antigen exposure following acute infection before complete viral suppression via ART impacts the quality of the memory T cell repertoire. In this study, we investigated this relationship to better understand how…