Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
CROI conference materials (eg, the conference program, Abstract eBook, electronic posters, CROI logo, etc) are protected by copyright. Permission to replicate or reproduce these elements, in whole or in part, must be obtained from the CROI Conference Manager, the International Antiviral Society-USA (IAS-USA). Study data (including figures within abstracts or electronic posters) are the property of the study authors. Permission to use data and figures cannot be given by IAS–USA unless it is for regulatory reasons. For more information, please email CROIabstracts@iasusa.org.
1277 Results
Background Polypharmacy, or the use of five or more non-ART prescription medications, promote neurologic disorders and geriatric syndromes. However, it is unknown if this is mediated by neuronal damage incurred by multiple medications, by inflammation, or by high comorbidity burden necessitating the use of multiple medications. To better understand how polypharmacy influences neurologic disorder in…
Background A subset of people who recover from acute COVID-19 develop a range of emergent or persistent symptoms lasting months to years, collectively termed Long COVID (LC). We investigated whether autoimmune antibodies in the CNS associate with neurologic Long COVID symptoms (n-LC). Methods Participants with LC (WHO criteria) and cognitive symptoms or headache enrolled in…
Background Due to its regulatory properties, adenosine has been recognized as a guardian molecule with many protective functions in and out of the brain. For example, HIV silencing in T-cells has been associated with upregulating the adenosine-producing ecto-5’-nucleotidase Nt5e (known as CD73). We hypothesized that under HIV-induced inflammatory conditions in the brain extracellular ATP/adenosine would increase and…
Background Central Nervous System (CNS) complications among people living with HIV (PWH) are common, but treatments remain elusive, likely due to underlying heterogeneity. Here, we aim to characterize neurobiological heterogeneity in PWH by leveraging machine learning and neuroimaging data in a large, well-characterized cohort. Methods We analyzed structural Magnetic Resonance Imaging (sMRI) data from 610…
Background Heavily treatment-experienced (HTE) persons with HIV (PWH) are characterized by long infection and treatment history, resistant viruses, and a significant burden of concomitant diseases. Since these features may be associated with HIV replication in the Central Nervous System (CNS), this study aimed to assess plasma CNS tissue markers in HTE versus controls. Methods HTE…
Background Neutralizing B cell responses are critical for sustained viral control in people with HIV (PWH). However, whether B cell alterations contribute to viral persistence in the central nervous system is unknown. To address this gap, we profiled the single B cell receptor (BCR) repertoire and transcriptomes in cerebrospinal fluid (CSF) and blood of PWH…
Background We and others have previously demonstrated that intact, transcriptionally competent HIV genomes persist within the brain of virally suppressed people with HIV (PWH). Long terminal repeats (LTRs) isolated from the brain of non-virally suppressed PWH are genetically distinct from those isolated in matched peripheral tissue and have a reduced responsiveness to select latency reversing…
Background The human gut has a high burden of HIV, but little is known about the phenotypes of HIV reservoir cells at this site or the influence of the local microenvironment. Here, we used standard and 40-parameter multiplexed ion beam imaging by time of flight (MIBI-TOF) microscopy to study the HIV reservoir and their associated environments…
Background In the current study, we test whether low level HIV replication is important in the pathogenesis of neurocognitive and neuroimaging biotypes, and independent of comorbidity and legacy effects. Methods 43 virally-suppressed clinically stable men with HIV (age 53±14 years, plasma and CSF <20-50 cp/mL) were included. Neurocognition, CSF neopterin, plasma and CSF HIV RNA…
Background Neddylation is essential for post-translational regulation of many cellular processes, including transcription and protein degradation. The NEDD8-activating enzyme inhibitor MLN4924 (MLN) can block degradation of HIV restriction factor APOBEC3G (A3G) in newly infected cells. Here we show that inhibiting neddylation via MLN reduces HIV reactivation from latency after treatment with latency reversing agents (LRAs).…