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1277 Results
Background Mitochondrial DNA variation is associated with multiple aging-related comorbidities among people with HIV (PWH). Data on the effect of inherited mitochondrial DNA variants on physical function among PWH are limited. Methods We included men with ≥2 visits from the Multicenter AIDS Cohort Study. Gait speed and grip strength were evaluated twice annually using standard methods…
Background Statins have pleiotropic effects beyond lowering LDL cholesterol, offering benefits in multiple cardiometabolic conditions and reducing chronic inflammation. These effects have the potential to also influence biological aging trajectories, reflected by frailty. The objective of this study was to compare frailty trajectories, in people with HIV (PWH) who used statins for primary cardiovascular prevention…
Background APOL1 gene risk variants (G1: S342G and I384M; and G2: del N388 and Y389) significantly contribute to genetic risk of chronic kidney disease (CKD), particularly in people living with HIV (PLWH). Shorter renal allograft survival has been demonstrated in kidney transplant recipients (KTR) without HIV where either donor or recipient kidney genotype included a…
Background Weight gain following ART initiation has been linked to an increased risk of diabetes among persons aging with HIV (PAH). We aimed to assess the impact of a hypothetical BMI maintenance program, implemented in the first 2 years after ART initiation, on cumulative diabetes risk over 7 years post-ART initiation. Methods The PEARL model…
Background Living with HIV infection and experiencing housing instability are both independently associated with early onset of aging-related comorbidities including frailty. However, few studies have examined the relationship between housing status and frailty among people with HIV (PWH). Methods We analyzed data from PWH engaged in care at 6 sites across the US within the…
Background Over 50% of people with HIV (PWH) in the United States (US) are older than 50 years and are at risk for a high lifetime burden of physical frailty, falls, and fall-related fractures. However, data on the long-term clinical and economic consequences of these events are sparse. We projected the survival gains and economic…
Background People with long-term controlled HIV (PWH) suffer from inflammaging, characterized by chronic inflammation and immunosenescence. As cannabis smokers display immune beneficial effects such as lower levels of inflammation and as the popularity of cannabidiol (CBD) products increases, we evaluated the safety of a full-spectrum cannabidiol drug for the first time on PWH. The new results presented herein…
Background Mitochondrial dysfunction is implicated in the development of heart failure, which is more common in people with HIV (PWH) than those without HIV (PWoH). Whether genetic variations in mitochondrial DNA (mtDNA) are related to cardiac dysfunction, specifically left ventricular diastolic dysfunction (LVDD), has not been well studied in PWH. Methods We included men from…
Background The Pitavastatin to REduce Physical Function Impairment and FRailty in HIV (PREPARE) substudy of REPRIEVE found small declines in physical function, and no evidence of pitavastatin effect. However, there was substantial individual variability, with some participants experiencing considerable declines. The purpose of this pre-specified exploratory analysis was to identify participants at a greater risk…
Background Transgender and gender diverse (TGD) people with HIV may experience high prevalences of psychiatric diagnoses due to the convergence of two marginalized social identities, HIV infection and gender minority. Utilizing multi-sourced data from the All of Us (AoU) Research Program, the current study aimed to examine the impact of HIV status on psychiatric diagnoses among…