Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
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1277 Results
Background Cognitive dysfunction is a common symptom of Long COVID (LC), but its underlying pathobiology is unclear. We hypothesized that multimodal structural brain MRI imaging in people with cognitive LC (c-LC) would demonstrate grey and white matter alterations in brain regions relevant to c-LC symptoms compared to no LC (n-LC) controls. Methods Individuals with c-LC (new self-reported…
Background Liver disease due to viral hepatitis is a leading cause of mortality in PWH. Elucidating host genes that affect HBV transcription may accelerate hepatitis B virus (HBV) cure discovery. We hypothesized that host genes modulate HBV transcription during nucleos(t)ide analogue (NUC) therapy. Methods We used mRNA-capture slides (10X Genomics) on liver biopsies from 14…
Background People with HIV (PWH) are at higher risk for visceral adiposity and enhanced inflammation, and lower neurocognitive function when compared to controls without HIV. In a recent randomized placebo-controlled clinical trial of the GLP1 receptor agonist semaglutide, we demonstrated that PWH with lipohypertrophy had a decrease in weight, visceral adipose tissue, and in several…
Background Hepatitis C virus (HCV) incidence is high among people with HIV (PWH) and people who inject drugs (PWID). Sexual transmission may also contribute to a higher HCV incidence in PWH, mainly among men who have sex with men (MSM). We report epidemiologic trends of incident HCV infection among PWH engaged in care in the…
Background The central nervous system (CNS) reservoir for HIV during ART has implications for both HIV cure and clinical outcomes. HIV DNA has been cross-sectionally detected in cerebrospinal fluid (CSF) cells but the longitudinal dynamics of HIV DNA in CSF during long-term suppressive ART are unknown. Methods 16 participants in ACTG A5321/A5341s who started ART…
Background Healthy individuals who contract SARS-CoV-2 exhibit structural brain changes after infection. To assess whether SARS-CoV-2 is associated with unique or additive brain effects among people with HIV (PWH), we capitalized on systematic longitudinal 3T MRIs captured in the RV254 acute HIV (AHI) Thai cohort to compare changes between PWH who did or did not…
Background Previous studies on brain volumes in people with HIV (PWH) who initiated antiretroviral therapy (ART) during acute HIV infection (AHI) were limited by the absence of a control group or brief follow-up periods. A recent cross-sectional analysis revealed larger volumes in regions vulnerable to HIV during AHI. Here, we compared longitudinal brain volume changes…
Background Alzheimer’s disease (AD) is the leading cause of dementia worldwide, and accurate diagnosis is crucial, including for people with HIV (PWH). Blood-based biomarkers for AD offer a promising, low-cost, non-invasive diagnostic alternative, but data are limited in PWH. Our study measured phosphorylated tau 217 (p-tau217)–the only blood-based biomarker currently recommended for diagnosing AD–and assessed…
Background The HIV reservoir in the central nervous system (CNS) poses a significant challenge to cure efforts, mostly by our limited understanding and access to this compartment Methods Tissue samples across 9 CNS regions, including 5 spinal cord (SC) segments (pons, medulla, cervical, lumbosacral, and thoracic spinal cord [TSC], frontal motor cortex [FC], basal ganglia…
Background Long-acting injectables may address barriers to HIV pre-exposure prophylaxis (PrEP), such as stigma and pill burden. In a Phase 3 trial in cisgender women, twice-yearly (Q6M) subcutaneous (SC) lenacapavir (LEN) (927 mg, in two 1.5 mL injections) was safe and 100% efficacious as PrEP, with high adherence among participants. We assessed the pharmacokinetics (PK) and safety…