Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
CROI conference materials (eg, the conference program, Abstract eBook, electronic posters, CROI logo, etc) are protected by copyright. Permission to replicate or reproduce these elements, in whole or in part, must be obtained from the CROI Conference Manager, the International Antiviral Society-USA (IAS-USA). Study data (including figures within abstracts or electronic posters) are the property of the study authors. Permission to use data and figures cannot be given by IAS–USA unless it is for regulatory reasons. For more information, please email CROIabstracts@iasusa.org.
1277 Results
Background CC genotype of the rs12979860 polymorphism on the lambda 4 interferon (IFNL4) gene has been related to spontaneous resolution of Hepatitis C virus (HCV) infection. The role of CC genotype in those who develop chronic HCV infection is still unknown, particularly notable during Human Immunodeficiency Virus (HIV) coinfection. To study its role in HCV/HIV…
Background The persistence of HIV-infected cells containing genetically-intact and replication-competent virus remains the main obstacle to achieving an HIV cure. Tuberculosis (TB) is the most prevalent opportunistic infection in people with HIV (PWH) but the impact of TB on the immune response to HIV, and the persistent HIV reservoir, is poorly understood. To address this…
Background Although antiretroviral therapy (ART) effectively improves the life expectancy among people living with HIV (PLWH), persistent chronic immune activation and inflammation remain a concern. Recent studies suggest that some miRNA species in extracellular vesicles (EVs) play a role in modulating inflammation. We thus hypothesized that dysregulation of EVs’ miRNAs during HIV infection may be associated…
Background HIV infection leads to significant loss of CD4 T lymphocytes (CD4TL), compromising immune function despite antiretroviral therapy (ART). People living with HIV (PLHIV) can be categorized as immune responders (IR) or immune non-responders (INR) based on their ability to achieve immune reconstitution. IR restore CD4TL counts >500 cells/mm³, while INR remain below this threshold…
Background HIV-2 is characterised by more indolent clinical progression than HIV-1, including decreased T-cell activation and limited immune exhaustion. However, it remains unclear how HIV subtypes impact the unconventional lymphocyte compartment, including mucosal-associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT), and Vδ2+ T-cells which mediate gut barrier defence and mucosal inflammation. To investigate whether the distinct clinical…
Background The advent of long-acting (LA) injectable ART has transformed the conceptualization of ART. However, there is a need for Real World Data on the impact of this novel approach on peripheral inflammation. The aim of this study was to investigate the dynamic changes in monocyte/macrophage subsets and their soluble activation markers in PLWH switching to…
Background CMV infection is a driver of immune activation and senescence, with greater impact in the setting of HIV-1 co-infection, where it contributes to CD8 T cell expansion and low CD4/CD8 T cell ratios. CMV replication occurs primarily in people with HIV-1 (PWH) with low blood CD4+ T cell counts, but occult CMV replication may…
Background A virulent HIV-1 subtype B clade (VB) first reported in 2022 (Wymant et al. 2022), is linked to higher viral loads (VL), faster CD4+ T-cell decline, and greater transmissibility. This presents significant challenges for clinical management due to its faster disease progression. The study aims to elucidate the effects of VB on clinical outcomes…
Background A transmitter/founder (T/F) HIV-1 strain can establish a productive infection in healthy individuals. HIV-1 envelope glycoproteins (Envs) mediate viral entry and have to maintain a delicate balance between evasion from neutralizing antibodies and entry compatibility. Escape from broadly neutralizing antibodies (bnAbs), which target highly conserved regions in HIV Envs, pose significant challenges to HIV-1…
Background Microbiome effects on mucosal HIV acquisition risk have received significant attention. Yet, little is known about mucosal microbiome variation between key populations, including cisgender men who have sex with men (MSM) and transgender women (TW) using feminizing hormone therapy (FHT) or across geographic locations. Methods We enrolled TW on FHT for ≥6 months [n=122;…