The April/May, 2021 issue of Topics in Antiviral Medicine™ (TAM) is the first of 2 issues that highlight the cutting-edge scientific advances that were presented at the virtual 2021 Conference on Retroviruses and Opportunistic Infections (CRO 2021). In this issue, new data on HIV prevention as well as epidemiologic trends and neurologic, metabolic, and opportunistic complications in HIV or SARS-CoV-2 are summarized. This issue offers up to 6.5 CME credits.

The next issue will include advances in basic science research, antiviral treatments for HIV or SARS-CoV-2, and liver diseases and viral hepatitis.