Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.

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Search Results

1277 Results

570 – Impact of Early ART Initiation With BIC/FTC/TAF on HIV-1 Reservoir Decay During Primary Infection

Background Viral reservoir is established early during primary HIV infection (PHI). Early antiretroviral therapy (ART) is essential to limit reservoir development. The aim of this work was to evaluate the impact of rapid bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment on intact and defective proviral HIV-1 DNA in people with PHI. Methods Multicenter, single-arm clinical trial in confirmed…

584 – Depletion of CX3CR1+ Effector CD8 TRM Cells Is Associated With HIV-1 Reservoir in the Colon on ART

Background The identification of host immune factors involved in the persistence of tissular HIV-1 reservoirs is crucial for the development of remission strategies. The intact HIV-1 reservoir is higher in the colon compared to other intestinal compartments at the chronic stage on ART, which may be related to the local loss of tissular resident memory…

500 – The Asymmetric Opening of HIV-1 Env by a Potent CD4 Mimetic Enables Anti-CoRBS Abs to Mediate ADCC

Background HIV-1 envelope glycoproteins (Env) from primary HIV-1 isolates typically adopt a “closed” conformation resistant to the binding of non-neutralizing antibodies (nnAbs). CD4-mimetic compounds (CD4mcs) “open-up” Env, sensitizing infected cells to antibody-dependent cellular cytotoxicity (ADCC) by CD4-induced (CD4i) nnAbs. Two CD4i nnAb families, anti-cluster A and anti-coreceptor binding site (CoRBS) Abs, are necessary for ADCC with…

493 – Population-Specific T-Cell Responses and Virologic Control After Analytical Treatment Interruption

Background Early ART initiation and broadly neutralizing anti-HIV antibodies (bnAbs) are associated with later ART-free HIV control more frequently in African women with clade C HIV compared to men with clade B HIV. T cells may mediate HIV control, but data among women are limited. We thus measured T cell responses in women and MSM+TG…

586 – Single Cell Characterization of the Gastrointestinal HIV Reservoir

Background Human gastrointestinal (GI) tissues are a major site of HIV-1 viral replication and persistence, but the nature of the persistent HIV-1 reservoir in the GI remains poorly described. Previous study has identified higher levels of viral DNA but lower levels of transcriptional initiation in the colon as compared to the peripheral blood.  Methods To…

519 – Women With HIV Have a Lower Frequency of Monocyte Reservoir Reactivation Than Men With HIV

Background There are known sex differences in HIV infection, latency, and immune responses. Women are overrepresented in some cohorts of immune controllers of HIV, raising questions about whether sex differences in immune responses track with features like spontaneous viral control. Previous studies addressed sex differences in the CD4 T cell reservoir and report that though…

565 – Multiomics Clustering Reveals Distinct HIV Reservoir Profiles in the 2000HIV Cohort

Background Multi-omics data integration offers potential to uncover hidden patterns among people living with HIV (PLWH). This study aimed to identify clusters of individuals with distinct viral reservoir characteristics and multi-omics profiles in the 2000HIV cohort. Methods Multi-omics data from 1,236 PLWH in the 2000HIV cohort (NCT03994835) were analyzed, including gene expression (58,347 genes, bulk…

554 – Sequencing of HIV-1 Proviruses in Large Infected T-Cell Clones Reveals a Predominance of Solo-LTRs

Background Most methods of amplifying and sequencing proviruses do not capture the flanking long terminal repeats (LTRs) because of technical difficulties related to sequence identity between these elements. Consequently, defective HIV-1 proviruses consisting of a single LTR (solo-LTR), a common proviral structure across retroviruses, are not detected and thus their frequency and significance are poorly…

487 – Mitochondrial Gene Variants Influence VARS2, HIV Reservoir, and CD4+ T Cells in HIV Controllers

Background Mitochondria are crucial for cellular energy metabolism and immune regulation, but their role in spontaneous HIV control remains unclear. We hypothesized that single nucleotide polymorphisms (SNPs) in mitochondrial-related genes influence HIV control. Methods SNP-set enrichment analysis was conducted to determine if SNPs in autosomal mitochondrial-related genes are enriched in HIV-control associated SNPs compared to…

541 – Autologous IgGs Mediate Log Reductions in HIV Infection in a PTC, Contributing to ART-Free Remission

Background In people living with HIV on suppressive ART, the latent reservoir is composed of archived viral variants that are either sensitive or resistant to autologous neutralizing antibodies (aNAbs), with the latter capable of causing rebound following treatment interruption. We hypothesized ART-free virologic control might be achieved if aNAbs developed to neutralize all inducible, replication-competent…