Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
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1277 Results
Background HIV-1 cure strategies require a comprehensive understanding of cellular phenotype of HIV tissue reservoirs for effective and selective targeting. While recent data have demonstrated the highly heterogeneous nature of peripheral blood CD4+ T cells subsets comprising the HIV reservoir of antiretroviral therapy (ART) treated people with HIV (PWH), CD4+ T follicular helper (Tfh) cells…
Background There is a paucity of understanding of how HIV latent reservoirs survive and expand, escape immune clearance, and reactivate upon ART cessation. The integration site (IS) of proviral DNA into the host genome could (i) determine the transcriptional status of the provirus and (ii) influence the expansion of infected cells. In this study, we…
Background Characterization of HIV-1 persistence in both CD4+ T cell and myeloid reservoirs within systemic tissues and the brain are goals of the cure field. Clade D HIV-1 infects both CD4+ T cells and macrophages. Thus, we have employed SHIV encoding a clade D transmitted/founder HIV-1 Env to study reservoirs in ART-suppressed rhesus macaques (RM).…
Background The LN factors regulating HIV reservoir maintenance, particularly in antiretroviral treated people living with HIV (cART PLWH), are not defined. Presumably, the interplay between innate (e.g. monocytes, dendritic cells) and adaptive immune cells, particularly TFH cells, a main HIV reservoir component, is critical for this maintenance. We have applied complementary methodologies to delineate the…
Background Antiretroviral therapy (ART) reduces but does not eliminate intracellular HIV-1 transcription in people with HIV (PWH). While proximal virus transcripts can be detected in blood and tissue, the presence of unspliced distal transcripts is less well characterized. Qualitatively, the sequences of HIV-1 caRNA that are induced by latency reversal agents (LRA) are less well…
Background The HIV reservoir is enriched for clonal CD4+ T-cells harboring intact proviruses after years of antiretroviral therapy (ART). In this study, we characterize the immunophenotypes of ‘authentic reservoir-harboring clones’ (ARCs) isolated and propagated from people living with HIV (PLWH) and aim to understand the contribution of these profiles to persistence. Methods Individual ARCs from…
Background The persistent HIV-1 reservoir is comprised of individual proviral clones with a corresponding integration site. The proviral landscape in the blood of long-term ART-suppressed persons with HIV-1(PWH) is often dominated by identical sequences, signifying antigen-driven proliferation. The clonal structure of the SIV reservoir during ART suppression is less well-characterized, particularly in the first 2 years…
Background Cure strategies that seek to permanently block reversal of HIV-1 latency remain largely unexplored. We previously showed that the HIV-1 antisense transcript AST induces a closed chromatin state at the HIV-1 5’LTR that blocks transcription and promotes latency in cell line models. Here, we assessed the ability of AST to prevent latency reversal in…
Background A major challenge in curing HIV is eliminating latent integrated proviral DNA from CD4+ T and myeloid cells. Recent clinical studies (EBT-101) using adeno-associated viral (AAV) vectors to deliver CRISPR for HIV eradication remained unsuccessful likely due to the limitations of AAV vectors, highlighting the need for alternative delivery systems like lipid nanoparticles (LNPs). To this end,…
Background HIV reservoirs in CD4⁺ T cells may be selected for the ability to evade immune clearance, hindering HIV cure efforts. Overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4⁺ T cells that survive cytotoxic T lymphocyte (CTL) exposure suggests a putative mechanism of immune resistance. This study investigated whether inhibition of EZH2…