Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.

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Search Results

1277 Results

611 – DNA Methylation Clocks Are Altered in Persons With Undetectable HIV and Correlate With Brain Aging

Background DNA methylation (DNAm) clocks are quantitative markers of biological aging. The first-generation Horvath and Hannum clocks closely track actual age, second-generation clocks such as PhenoAge and GrimAge are sensitive to morbidity and mortality, and the third-generation DunedinPACE model estimates individual longitudinal “pace of aging.” Multiple studies have linked HIV infection with increased DNAm age;…

587 – HIV Transcriptional Regulation in the CNS of ART-Suppressed People With HIV

Background We and others have previously demonstrated that intact, transcriptionally competent HIV genomes persist within the brain of virally suppressed people with HIV (PWH). Long terminal repeats (LTRs) isolated from the brain of non-virally suppressed PWH are genetically distinct from those isolated in matched peripheral tissue and have a reduced responsiveness to select latency reversing…

585 – HIV Reservoir in Jejunum Exhibits Distinct Phenotypic Features and Evokes Innate Cell Redistribution

Background The human gut has a high burden of HIV, but little is known about the phenotypes of HIV reservoir cells at this site or the influence of the local microenvironment. Here, we used standard and 40-parameter multiplexed ion beam imaging by time of flight (MIBI-TOF) microscopy to study the HIV reservoir and their associated environments…

628 – Unmasking the Independent Role of CSF HIV RNA Dynamics by Single Copy Assay in Neurobiotypes

Background In the current study, we test whether low level HIV replication is important in the pathogenesis of neurocognitive and neuroimaging biotypes, and independent of comorbidity and legacy effects. Methods 43 virally-suppressed clinically stable men with HIV (age 53±14 years, plasma and CSF <20-50 cp/mL) were included. Neurocognition, CSF neopterin, plasma and CSF HIV RNA…

522 – HIV Burden Is Associated With Specific Bacteriome Profiles Relative to Specific Gut Segments

Background We assessed whether the gut bacteriome affects the size and activity of HIV reservoir in the human gut. Since each gut segment has a different immune and bacteriome environment, we also aimed at identifying a core bacteriome that is associated with HIV reservoir consistently and similarly across all the segments Methods Tissue samples of…

605 – Longitudinal Changes in Neuronal Markers and Associations With ART Initiation and Cognitive Function

Background Improvement in cognitive function is described in persons with HIV commencing ART for the first time. We assessed the impact of initiating either dual or triple ART on longitudinal changes in biomarkers of neuronal inflammation and injury, and their associations with cognitive function. Methods Biomarker concentrations were assessed at baseline (W0) and after 96…

518 – HIV Can Persist in Multiple Subsets of SARS-CoV-2-Specific CD4+ T Cells in Tissues During ART

Background Transcriptionally-active cells (TAC) that produce HIV RNA persist during ART contribute to chronic inflammation and co-morbidities, and can lead to viral rebound upon ART interruption. However, our understanding of these cells – particularly within tissues – is limited. We implemented HIV-seq, a technique we established to efficiently identify HIV+ cells by scRNAseq, to characterize…

502 – Targeting TCF-1 to Potentiate the Functional Capacity of HIV/SIV-Specific CD8+ T Cells

Background The transcription factor T cell factor 1 (TCF-1) plays a critical role in maintaining functional memory CD8+ T cells and regulation of their proliferation capacity. TCF-1 expression in HIV-specific CD8+ T cells has been associated with viral control and may be important for promoting the functional activity of HIV-specific CD8+ T cells. Glycogen synthase kinase-3 (GSK-3) inhibitors…

514 – CD4+ T Cells Harboring Inducible HIV Genomes Display a Senescent-Like Phenotype

Background Latently HIV-infected cells persist during antiretroviral therapy (ART) and these viral reservoirs inevitably trigger a viral rebound when treatment is interrupted. Identifying the mechanisms contributing to the persistence of these reservoirs is essential to the development of strategies aimed at eradicating them. In this study, we used a single-cell approach to measure multiple parameters…

492 – Post-Treatment HIV Controllers Exhibit Reduced Plasma Markers of Inflammation and Metabolic Stress

Background A rare subset of people with HIV (PWH) on antiretroviral therapy (ART), known as post-treatment controllers (PTCs), can maintain viral suppression for extended periods after treatment interruption (TI). The mechanisms underlying this clinically valuable phenotype remain unclear and are likely multifactorial, necessitating further comprehensive analysis. Methods Pre-TI levels of 247 inflammation and immunomodulatory markers…